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CPT1A-mediated fatty acid oxidation promotes colorectal cancer cell metastasis by inhibiting anoikis
by
Zhao, Qi
, Xie, Dan
, Liu, Ze-Xian
, Xu, Rui-Hua
, Shi, Ming
, Zeng, Zhao-Lei
, Pu, Heng-Ying
, Yu, Kai
, Wang, Feng
, He, Ming-Ming
, Kang, Tie-Bang
, Li, Bo
, Jia, Wei-Hua
, Ju, Huai-Qiang
, Wang, Ying-Nan
, Lu, Yun-Xin
, Wang, Zi-Xian
, Li, Ting
, Wang, Yun
, Wu, Qi-Nian
, Huang, Peng
, Lu, Jiahuan
in
Animals
/ Anoikis
/ Anoikis - physiology
/ Caco-2 Cells
/ Cancer metastasis
/ Care and treatment
/ Carnitine O-Palmitoyltransferase - metabolism
/ Cell Line, Tumor
/ Colorectal cancer
/ Colorectal carcinoma
/ Colorectal Neoplasms - genetics
/ Colorectal Neoplasms - metabolism
/ Colorectal Neoplasms - pathology
/ Complications and side effects
/ Enzymes
/ Fatty acids
/ Fatty Acids - metabolism
/ Gene Expression Regulation, Neoplastic - physiology
/ Genes
/ Genetic aspects
/ HCT116 Cells
/ Health aspects
/ HT29 Cells
/ Humans
/ Lipid Metabolism - physiology
/ Male
/ Medical schools
/ Metastases
/ Metastasis
/ Mice
/ Mice, Inbred BALB C
/ Mice, Nude
/ Neoplasm Metastasis - pathology
/ Oxidation
/ Oxidation-Reduction
/ Oxidation-reduction reactions
/ Reactive oxygen species
/ Reactive Oxygen Species - metabolism
/ Risk factors
/ Transferases
2018
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CPT1A-mediated fatty acid oxidation promotes colorectal cancer cell metastasis by inhibiting anoikis
by
Zhao, Qi
, Xie, Dan
, Liu, Ze-Xian
, Xu, Rui-Hua
, Shi, Ming
, Zeng, Zhao-Lei
, Pu, Heng-Ying
, Yu, Kai
, Wang, Feng
, He, Ming-Ming
, Kang, Tie-Bang
, Li, Bo
, Jia, Wei-Hua
, Ju, Huai-Qiang
, Wang, Ying-Nan
, Lu, Yun-Xin
, Wang, Zi-Xian
, Li, Ting
, Wang, Yun
, Wu, Qi-Nian
, Huang, Peng
, Lu, Jiahuan
in
Animals
/ Anoikis
/ Anoikis - physiology
/ Caco-2 Cells
/ Cancer metastasis
/ Care and treatment
/ Carnitine O-Palmitoyltransferase - metabolism
/ Cell Line, Tumor
/ Colorectal cancer
/ Colorectal carcinoma
/ Colorectal Neoplasms - genetics
/ Colorectal Neoplasms - metabolism
/ Colorectal Neoplasms - pathology
/ Complications and side effects
/ Enzymes
/ Fatty acids
/ Fatty Acids - metabolism
/ Gene Expression Regulation, Neoplastic - physiology
/ Genes
/ Genetic aspects
/ HCT116 Cells
/ Health aspects
/ HT29 Cells
/ Humans
/ Lipid Metabolism - physiology
/ Male
/ Medical schools
/ Metastases
/ Metastasis
/ Mice
/ Mice, Inbred BALB C
/ Mice, Nude
/ Neoplasm Metastasis - pathology
/ Oxidation
/ Oxidation-Reduction
/ Oxidation-reduction reactions
/ Reactive oxygen species
/ Reactive Oxygen Species - metabolism
/ Risk factors
/ Transferases
2018
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CPT1A-mediated fatty acid oxidation promotes colorectal cancer cell metastasis by inhibiting anoikis
by
Zhao, Qi
, Xie, Dan
, Liu, Ze-Xian
, Xu, Rui-Hua
, Shi, Ming
, Zeng, Zhao-Lei
, Pu, Heng-Ying
, Yu, Kai
, Wang, Feng
, He, Ming-Ming
, Kang, Tie-Bang
, Li, Bo
, Jia, Wei-Hua
, Ju, Huai-Qiang
, Wang, Ying-Nan
, Lu, Yun-Xin
, Wang, Zi-Xian
, Li, Ting
, Wang, Yun
, Wu, Qi-Nian
, Huang, Peng
, Lu, Jiahuan
in
Animals
/ Anoikis
/ Anoikis - physiology
/ Caco-2 Cells
/ Cancer metastasis
/ Care and treatment
/ Carnitine O-Palmitoyltransferase - metabolism
/ Cell Line, Tumor
/ Colorectal cancer
/ Colorectal carcinoma
/ Colorectal Neoplasms - genetics
/ Colorectal Neoplasms - metabolism
/ Colorectal Neoplasms - pathology
/ Complications and side effects
/ Enzymes
/ Fatty acids
/ Fatty Acids - metabolism
/ Gene Expression Regulation, Neoplastic - physiology
/ Genes
/ Genetic aspects
/ HCT116 Cells
/ Health aspects
/ HT29 Cells
/ Humans
/ Lipid Metabolism - physiology
/ Male
/ Medical schools
/ Metastases
/ Metastasis
/ Mice
/ Mice, Inbred BALB C
/ Mice, Nude
/ Neoplasm Metastasis - pathology
/ Oxidation
/ Oxidation-Reduction
/ Oxidation-reduction reactions
/ Reactive oxygen species
/ Reactive Oxygen Species - metabolism
/ Risk factors
/ Transferases
2018
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CPT1A-mediated fatty acid oxidation promotes colorectal cancer cell metastasis by inhibiting anoikis
Journal Article
CPT1A-mediated fatty acid oxidation promotes colorectal cancer cell metastasis by inhibiting anoikis
2018
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Overview
Anoikis is a critical obstacle to cancer metastasis. Colorectal cancer (CRC) exhibits a high rate of metastasis, leading to death, and the mechanisms involved in anoikis resistance are still unclear. We identified that the fatty acid oxidation (FAO) pathway was activated in detached CRC cells. Multiple genes in the FAO pathway, specifically the rate-limiting enzyme CPT1A, were upregulated in CRC cells grown in suspension. Reactive oxygen species elimination mediated by CPT1A in CRC cells was vital to anoikis resistance. In vivo experiments showed that CPT1A-suppressed CRC cells colonized the lung at a much lower rate than normal CRC cells, suggesting that CPT1A-mediated FAO activation increased metastatic capacity. In clinical tissue specimens from CRC patients, elevated expression of CPT1A was observed in metastatic sites compared with primary sites. Our results demonstrate that CPT1A-mediated FAO activation induces CRC cells to resist anoikis, suggesting that CPT1A is an attractive target for treating metastatic CRC.
Publisher
Nature Publishing Group
Subject
/ Anoikis
/ Carnitine O-Palmitoyltransferase - metabolism
/ Colorectal Neoplasms - genetics
/ Colorectal Neoplasms - metabolism
/ Colorectal Neoplasms - pathology
/ Complications and side effects
/ Enzymes
/ Gene Expression Regulation, Neoplastic - physiology
/ Genes
/ Humans
/ Lipid Metabolism - physiology
/ Male
/ Mice
/ Neoplasm Metastasis - pathology
/ Oxidation-reduction reactions
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