Journal Article

α3 Chains of type V collagen regulate breast tumour growth via glypican-1

Izzi, Valerio, Ge, Gaoxiang, Greenspan, Daniel S., Huang, Guorui

2017

Overview

Pericellular α3(V) collagen can affect the functioning of cells, such as adipocytes and pancreatic β cells. Here we show that α3(V) chains are an abundant product of normal mammary gland basal cells, and that α3(V) ablation in a mouse mammary tumour model inhibits mammary tumour progression by reducing the proliferative potential of tumour cells. These effects are shown to be primarily cell autonomous, from loss of α3(V) chains normally produced by tumour cells, in which they affect growth by enhancing the ability of cell surface proteoglycan glypican-1 to act as a co-receptor for FGF2. Thus, a mechanism is presented for microenvironmental influence on tumour growth. α3(V) chains are produced in both basal-like and luminal human breast tumours, and its expression levels are tightly coupled with those of glypican-1 across breast cancer types. Evidence indicates α3(V) chains as potential targets for inhibiting tumour growth and as markers of oncogenic transformation. Collagen has a role in cancer and is particularly important for breast cancer. Here the authors show that the expression of α3 type V collagen and one of its receptors- glipican-1- in the same cell, contributes to a deregulated growth of breast cancer cells.

• Publisher: Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
• Subject: 13/1 / 13/106 / 13/51 / 13/89 / 14/32 / 14/63 / 631/67/327 / 631/80/83 / 64/110 / 64/60 / Animals / Breast Neoplasms - metabolism / Collagen - genetics / Collagen - metabolism / Collagen Type V - genetics / Collagen Type V - metabolism / Female / Gene Expression Regulation, Neoplastic / Glypicans - genetics / Glypicans - metabolism / Humanities and Social Sciences / Humans / Mammary Neoplasms, Animal / Mice / Mice, Knockout / multidisciplinary / Science / Science (multidisciplinary)