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Identification and validation of an immunogenic subtype of gastric cancer with abundant intratumoural CD103+CD8+ T cells conferring favourable prognosis
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Identification and validation of an immunogenic subtype of gastric cancer with abundant intratumoural CD103+CD8+ T cells conferring favourable prognosis
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Identification and validation of an immunogenic subtype of gastric cancer with abundant intratumoural CD103+CD8+ T cells conferring favourable prognosis
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Journal Article
Identification and validation of an immunogenic subtype of gastric cancer with abundant intratumoural CD103+CD8+ T cells conferring favourable prognosis
2020
Overview
Background
Intratumoural CD103
+
CD8
+
T cells have been linked to prolonged survival in several malignancies. However, the clinical significance of CD103
+
CD8
+
T cells in gastric cancer remains unexplored.
Methods
Gastric cancer tissues from Zhongshan Hospital and data from Gene Expression Omnibus were obtained and analysed. Immunohistochemistry and flow cytometry were performed to detect the number and phenotypical characteristics of CD103
+
CD8
+
T cells. The effect of programmed cell death protein-1 (PD-1) blockade on CD103
+
CD8
+
T cells was evaluated with the use of an in vitro study based on fresh tumour tissues.
Results
CD103
+
CD8
+
T cells predicted superior overall survival and provided better prognostic power than total CD8
+
T cells in gastric cancer. Patients with high CD103
+
CD8
+
T cell infiltration also gained more benefit from adjuvant chemotherapy. Flow cytometry analysis showed that CD103
+
CD8
+
T cells exerted superior anti-tumour effects with stronger retention capacity and cytotoxicity. Moreover, an in vitro study showed that CD103
+
CD8
+
T cells were more functionally restored after PD-1 blockade than CD103
-
CD8
+
T cells.
Conclusions
CD103
+
CD8
+
T cells might be a useful marker to predict prognosis and therapeutic efficacy for gastric cancer patients. Efforts to increase intratumoural CD103
+
CD8
+
T cell frequency might be a novel therapeutic strategy in gastric cancer.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Aged
/ Biomedical and Life Sciences
/ CD8-Positive T-Lymphocytes - immunology
/ Female
/ Gene Expression Regulation, Neoplastic - genetics
/ Gene Expression Regulation, Neoplastic - immunology
/ Humans
/ Integrin alpha Chains - immunology
/ Lymphocytes, Tumor-Infiltrating
/ Male
/ Oncology
/ Patients
/ Programmed Cell Death 1 Receptor - genetics
/ Stomach Neoplasms - classification
/ Stomach Neoplasms - genetics
/ Stomach Neoplasms - immunology
/ Stomach Neoplasms - pathology
/ Tumors
