Journal Article

Autologous nerve graft repair of different degrees of sciatic nerve defect: stress and displacement at the anastomosis in a three-dimensional fnite element simulation model

Luo, Min, Piao, Cheng-dong, Li, Peng, Yang, Kun

2015

Overview

In the repair of peripheral nerve injury using autologous or synthetic nerve grafting, the magnitude of tensile forces at the anastomosis affects its response to physiological stress and the ultimate success of the treatment. One-dimensional stretching is commonly used to measure changes in tensile stress and strain; however, the accuracy of this simple method is limited. Therefore, in the present study, we established three-dimensional finite element models of sciatic nerve defects repaired by autologous nerve grafts. Using PRO E 5.0 finite element simulation software, we calculated the maximum stress and displacement of an anastomosis under a 5 N load in 10-, 20-, 30-, 40-mm long autologous nerve grafts. We found that maximum displacement increased with graft length, consistent with specimen force. These findings indicate that three-dimensional finite element simulation is a feasible method for analyzing stress and displacement at the anastomosis after autologous nerve grafting.

• Publisher: Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,Medknow Publications & Media Pvt Ltd,Wolters Kluwer Medknow Publications
• Subject: Abnormalities / active zone stability / Alzheimer′s disease / Apelin-13 / apoplexy / apoptosis / autologous nerve grafting / axon pathfinding / axonal regeneration / Bcl-2 / bibliometric analysis / biomaterial / biomaterials / brain / brain activity / brain injury / brain-derived neurotrophic factor / Care and treatment / caspase-3 / cell differentiation / cell migration / cell transplant / cell transplantation / central nervous system / cerebral ischemia/reperfusion injury / cerebral subarachnoid hemorrhage / citation analysis / CiteSpace III / cognition / Computer simulation / CX3 chemokine receptor 1 / dendrites / dephosphorylation / Diagnosis / displacement / divalent metal transporter 1 / doublecortin / Drosophila / epimedium herb / epineurial suturing / exosome / extracellular vesicle / ferroportin 1 / fractalkine / functional magnetic resonance imaging / ginsenoside Rg1 / GSK-3ß / healthy / hemodynamic phases / Huntington′s disease / hypoxic-ischemic brain damage / inhibition / injury / ischemia / kudzuvine root / lateral intracerebroventricular injection / Liprin-α / living scaffolds / load / metabolic crises / mice / microglia / microRNA / microRNA-124 / microvesicle / milkvetch root / mutant huntingtin / nanotechnology / nerve apoptosis / nerve gap / nerve reconstruction / Nerve regeneration / neural progenitor / neural regeneration / neural stem cells / neural tissue engineering / neurite outgrowth / neurodegeneration / neurodegenerative disease / neurodegenerative diseases / neurogenesis / neurogenic bladder / neuroimaging / neuromuscular junction / neuron / neuronal maturation / neuronal survival / neuroprotection / neuroregeneration / neurotrauma / newborn neurons / NSFC grants / participants / peripheral nerve injury / Peripheral nervous system diseases / peroxisome proliferator-activated receptor gamma coactivator 1-alpha / Physiological aspects / Physiology / plasticity / PP2A / Ras/Raf/Erk1/2 signaling pathway / regeneration / regenerative medicine / regional homogeneity / regulation / repair / Schwann cell / Sciatic nerve / sciatic nerve injury / Software / spinal cord injury / SRY-related HMG box transcription factor 9 / stem cell / stress / subacute / Syd-1 / synaptic maturation / therapy / three-dimensional finite element models / tissue engineering / transgenic animal models / visualization analysis / volunteers / Web of Science database