Journal Article

Imaging serpiginous choroidopathy with spectral domain optical coherence tomography

Gregori, Giovanni, Rosenfeld, Philip J, Puliafito, Carmen A, Rich, Ryan, Punjabi, Omar S, Flynn, Jr, Harry W, Davis, Janet L, Lujan, Brandon J

2008

Overview

The use of spectral domain optical coherence tomography (SD-OCT) in the study of chronic serpiginous choroiditis was evaluated. Two patients with chronic serpiginous choroiditis were imaged using two prototype SD-OCT systems (6-microm axial resolution). Raster scans covering 6 x 6 X 2-mm regions of the retina were obtained, enabling the study of different retinal cross-sectional images. Thickness maps were obtained after segmentation of retinal layers, which could be compared with those on follow-up. SD-OCT allowed the visualization of the cross-sectional retinal architecture at different horizontal positions. Superimposition of SD-OCT generated reconstructed fundus images with fundus photographs provided accurate images registration. Segmentation of retinal layers provided thickness maps and higher-density improved visualization of photoreceptor layer, cysts, and atrophy, which was useful in following change in disease activity over time. The researchers concluded that SD-OCT is a useful tool to study disease morphology and follow-up of chronic serpiginous choroiditis.

• Publisher: SLACK INCORPORATED
• Subject: Aged, 80 and over / Atrophy / Blood vessels / Capillaries - pathology / Chorioretinitis - pathology / Choroid - blood supply / Choroid - pathology / Cysts / Diagnosis, Differential / Edema / Female / Follow-Up Studies / Humans / Image Processing, Computer-Assisted - methods / Image reconstruction / Image segmentation / Male / Medical imaging / Middle Aged / Morphology / Ophthalmology / Optical Coherence Tomography / Patients / Photography / Photoreceptors / Pigment Epithelium of Eye - pathology / Raster scanning / Registration / Retina / Thickness / Tomography / Tomography, Optical Coherence - methods / Visual acuity / Visualization