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DNA methylation abundantly associates with fetal alcohol spectrum disorder and its subphenotypes
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DNA methylation abundantly associates with fetal alcohol spectrum disorder and its subphenotypes
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Journal Article
DNA methylation abundantly associates with fetal alcohol spectrum disorder and its subphenotypes
2019
Overview
Fetal alcohol spectrum disorder (FASD) involves prenatal growth delay, impaired facial and CNS development and causes severe clinical, social-economic burdens. Here, we aim to detect DNA-methylation aberrations associated with FASD and potential FASD diagnostic and prognostic biomarkers.
The FASD diagnosis was established according to golden-standard protocols in a discovery and independent replication cohort. Genome-wide differential methylation association and replication analyses were performed.
We identified several loci that were robustly associated with FASD or one of its sub phenotypes. Our findings were evaluated using previously reported genome-wide surveys.
We have detected robust FASD associated differentially methylated positions and differentially methylated regions for FASD in general and for FASD subphenotypes, in other words on growth delay, impaired facial and CNS development.
Publisher
Future Science Ltd,Future Medicine Ltd
Subject
/ Autism
/ Cancer
/ Child
/ Defects
/ Delay
/ DNA
/ Dystrophin-Associated Proteins - genetics
/ Ethanol
/ Female
/ fetal alcohol spectrum disorder
/ Fetal Alcohol Spectrum Disorders - diagnosis
/ Fetal Alcohol Spectrum Disorders - genetics
/ Genome-Wide Association Study
/ Genomes
/ Humans
/ Infant
/ Male
/ Patients
/ Receptors, Tumor Necrosis Factor - genetics
/ Studies
