Asset Details
Do you wish to reserve the book?
Phenolic Compounds with Antioxidant Properties from Canola Meal Extracts Inhibit Adipogenesis
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Phenolic Compounds with Antioxidant Properties from Canola Meal Extracts Inhibit Adipogenesis
Do you wish to request the book?
Phenolic Compounds with Antioxidant Properties from Canola Meal Extracts Inhibit Adipogenesis
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Phenolic Compounds with Antioxidant Properties from Canola Meal Extracts Inhibit Adipogenesis
2019
Overview
The extraction of phenolic compounds from canola meal produces functional health products and renders the canola meal a more digestible animal feed. The extracted phenolics may have novel bioactivity worth investigation. In this study, several solvents were evaluated for their ability to extract phenolic compounds from canola meal: water (WE) and various 80% organic solvent/water mixtures of methanol (ME), acetone (AE), ethanol (EE), butanol (BE), chloroform (CE) and hexane (HE). The in vitro antioxidant and anti-obesity properties of various extracts were investigated. Anti-obesity properties were studied using adipogenic differentiation inhibition of a murine mesenchymal stem cell line (C3H10T1/2) and a pancreatic lipase inhibition assay. AE, ME, and BE showed significant (p < 0.05) adipogenesis and pancreatic lipase inhibitory activities and may have more pharmacological properties. AE down-regulated the gene expression of the major adipogenic transcription factor, peroxisome proliferator-activated receptor gamma (PPARγ), correlating to phenolic content in a dose-dependent manner. The chemical characterization of AE revealed the presence of sinapic acid, ferulic acid, and kaempferol derivatives as main bioactive phenols.
Publisher
MDPI AG,MDPI
Subject
/ Animals
/ Canola
/ Chromatography, High Pressure Liquid
/ Enzymes
/ Gene Expression Regulation - drug effects
/ Intracellular Space - metabolism
/ Lipase - antagonists & inhibitors
/ Lipid Metabolism - drug effects
/ Mice
/ Obesity
/ Oilseeds
/ Phenols
/ Plant Extracts - pharmacology
/ Proteins
/ Solvents
