Journal Article

Chemokines Modulate Immune Surveillance in Tumorigenesis, Metastasis, and Response to Immunotherapy

Vilgelm, Anna E., Richmond, Ann

2019

Overview

Chemokines are small secreted proteins that orchestrate migration and positioning of immune cells within the tissues. Chemokines are essential for the function of the immune system. Accumulating evidence suggest that chemokines play important roles in tumor microenvironment. In this review we discuss an association of chemokine expression and activity within the tumor microenvironment with cancer outcome. We summarize regulation of immune cell recruitment into the tumor by chemokine-chemokine receptor interactions and describe evidence implicating chemokines in promotion of the \"inflamed\" immune-cell enriched tumor microenvironment. We review both tumor-promoting function of chemokines, such as regulation of tumor metastasis, and beneficial chemokine roles, including stimulation of anti-tumor immunity and response to immunotherapy. Finally, we discuss the therapeutic strategies target tumor-promoting chemokines or induce/deliver beneficial chemokines within the tumor focusing on pre-clinical studies and clinical trials going forward. The goal of this review is to provide insight into comprehensive role of chemokines and their receptors in tumor pathobiology and treatment.

• Publisher: Frontiers Media SA,Frontiers Media S.A
• Subject: Animals / Antigens / Antineoplastic Agents, Immunological - pharmacology / Antineoplastic Agents, Immunological - therapeutic use / Biomarkers / Breast cancer / cancer / Carcinogenesis - immunology / chemokine / chemokine receptor / Chemokine receptors / Chemokines / Chemokines - metabolism / Chemokines - pharmacology / Chemokines - therapeutic use / Clinical trials / Cytokines / Dendritic cells / Disease Progression / Fibroblasts / Humans / immune surveillance / Immune system / immune therapy / Immunologic Surveillance / Immunology / Immunomodulation / Immunosurveillance / Immunotherapy / Inflammation / Leukocytes / Ligands / Lymphocytes / Medical prognosis / Metastases / metastasis / Molecular Targeted Therapy / Neoplasm Metastasis / Neoplasm Staging / Neoplasms - immunology / Neoplasms - mortality / Neoplasms - pathology / Neoplasms - therapy / Neutrophils / Prognosis / Receptors, Chemokine - metabolism / T cell receptors / Treatment Outcome / Tumor microenvironment / Tumorigenesis