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Synapses Form in Skeletal Muscles Lacking Neuregulin Receptors

by Escher, P , Lloyd, K. C , Mueller, U , Courtet, M , Bezakova, G , Brenner, H. R , Blindenbacher, A , Lacazette, E , Landmann, L

in Agrin - physiology / Alleles / Animals / Animals, Newborn / Biological and medical sciences / Body Weight / Cells / Cells, Cultured / Developmental Programs / Fundamental and applied biological sciences. Psychology / Genes / Genes, erbB / Genes, erbB-2 / Individualized Instruction / Membrane Potentials / Messenger RNA / Mice / Motor Endplate - metabolism / Motor Endplate - physiology / Motor Endplate - ultrastructure / Motor neurons / Muscle fibers / Muscle, Skeletal - innervation / Muscle, Skeletal - ultrastructure / Muscles / Muscular system / Mutation / Nerves / Neuregulins - metabolism / Neuromuscular Junction - embryology / Neuromuscular Junction - metabolism / Neuromuscular Junction - physiology / Neuromuscular Junction - ultrastructure / Neurons / Presynaptic Terminals - physiology / Receptor, Epidermal Growth Factor - genetics / Receptor, Epidermal Growth Factor - physiology / Receptor, ErbB-2 - genetics / Receptor, ErbB-2 - physiology / Receptor, ErbB-4 / Receptors / Receptors, Cholinergic - chemistry / Receptors, Cholinergic - genetics / Receptors, Cholinergic - metabolism / Recombination, Genetic / RNA, Messenger - genetics / RNA, Messenger - metabolism / Schwann cells / Schwann Cells - physiology / Signal Transduction / skeletal muscle / Striated muscle. Tendons / synapse / Synapses / Synaptic Transmission / T cell receptors / Vertebrates: osteoarticular system, musculoskeletal system

2005

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Synapses Form in Skeletal Muscles Lacking Neuregulin Receptors

by Escher, P , Lloyd, K. C , Mueller, U , Courtet, M , Bezakova, G , Brenner, H. R , Blindenbacher, A , Lacazette, E , Landmann, L

2005

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Synapses Form in Skeletal Muscles Lacking Neuregulin Receptors

by Escher, P , Lloyd, K. C , Mueller, U , Courtet, M , Bezakova, G , Brenner, H. R , Blindenbacher, A , Lacazette, E , Landmann, L

2005

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Journal Article

Synapses Form in Skeletal Muscles Lacking Neuregulin Receptors

Escher, P,

Lloyd, K. C,

Mueller, U,

Courtet, M,

Bezakova, G,

Brenner, H. R,

Blindenbacher, A,

Lacazette, E,

Landmann, L

2005

Overview

The formation of the neuromuscular junction (NMJ) is directed by reciprocal interactions between motor neurons and muscle fibers. Neuregulin (NRG) and Agrin from motor nerve terminals are both implicated. Here, we demonstrate that NMJs can form in the absence of the NRG receptors ErbB2 and ErbB4 in mouse muscle. Postsynaptic differentiation is, however, induced by Agrin. We therefore conclude that NRG signaling to muscle is not required for NMJ formation. The effects of NRG signaling to muscle may be mediated indirectly through Schwann cells.

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Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

Agrin - physiology

/ Alleles

/ Animals

/ Animals, Newborn

/ Biological and medical sciences

/ Body Weight

/ Cells