Journal Article

A Randomized, Controlled Trial of Total Knee Replacement

Arendt-Nielsen, Lars, Skou, Søren T, Laursen, Mogens B, Rasmussen, Sten, Roos, Ewa M, Simonsen, Ole, Rathleff, Michael S

2015

Overview

In patients with knee osteoarthritis, total knee replacement followed by nonsurgical treatment resulted in greater pain relief and functional improvement after 12 months than did nonsurgical treatment alone, but it was associated with a higher number of serious adverse events. Total knee replacement is considered to be an effective treatment for end-stage knee osteoarthritis. 1 The number of total knee replacements performed each year in the United States has increased dramatically, from 31.2 per 100,000 person-years during the period 1971–1976 to 220.9 during the period 2005–2008. 2 In 2012, more than 670,000 total knee replacements were performed in the United States alone, with corresponding aggregate charges of $36.1 billion. 3 The number of total knee replacements is expected to increase as the average age of the population increases, 4 which highlights the associated future economic burden. Despite the large number of procedures performed annually, . . .

• Publisher: Massachusetts Medical Society
• Subject: Activities of Daily Living / Aged / Analgesics - therapeutic use / Arthritis / Arthroplasty, Replacement, Knee - rehabilitation / Clinical trials / Combined Modality Therapy / Evidence-based medicine / Exercise Therapy / Female / Follow-Up Studies / Foot Orthoses / Humans / Intention to Treat Analysis / Joint replacement surgery / Knee / Male / Middle Aged / Motivation / Osteoarthritis / Osteoarthritis, Knee - drug therapy / Osteoarthritis, Knee - surgery / Osteoarthritis, Knee - therapy / Pain / Pain management / Patients / Postoperative Complications / Quality of Life