Journal Article

Structure and Biological Activity of Ergostane-Type Steroids from Fungi

Zhabinskii, Vladimir N., Drasar, Pavel, Khripach, Vladimir A.

2022

Overview

Mushrooms are known not only for their taste but also for beneficial effects on health attributed to plethora of constituents. All mushrooms belong to the kingdom of fungi, which also includes yeasts and molds. Each year, hundreds of new metabolites of the main fungal sterol, ergosterol, are isolated from fungal sources. As a rule, further testing is carried out for their biological effects, and many of the isolated compounds exhibit one or another activity. This study aims to review recent literature (mainly over the past 10 years, selected older works are discussed for consistency purposes) on the structures and bioactivities of fungal metabolites of ergosterol. The review is not exhaustive in its coverage of structures found in fungi. Rather, it focuses solely on discussing compounds that have shown some biological activity with potential pharmacological utility.

• Publisher: MDPI AG,MDPI
• Subject: Agaricales / Androgens / anticancer / antiviral / Bioavailability / Biological activity / Cancer / Cell growth / Chronic obstructive pulmonary disease / Cytokines / Cytotoxicity / Diabetes / ergosteroids / ergosterol / Ergosterol - analogs & derivatives / Ergosterol - metabolism / Ergosterol - pharmacology / Experiments / Fungi / Fungi - metabolism / Glucose / Kinases / Lungs / mushrooms / Oral administration / Oxidative stress / Prostate / Review / Steroids / Steroids - metabolism / Steroids - pharmacology / Sterols / Sterols - metabolism / Tumor necrosis factor-TNF