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Sotatercept for Pulmonary Arterial Hypertension within the First Year after Diagnosis

by Meyer, Gisela , Brambatti, Michela , Miller, Barry , Koglin, Joerg , Humbert, Marc , Olsson, Karen M. , Patel, Mahesh J. , Shi, Yaru , Badesch, David B. , Waxman, Aaron B. , Cornell, Alexandra G. , Hoeper, Marius M. , Kopeć, Grzegorz , Mackenzie, Harald S. , Souza, Rogerio , Fu, Wei , Gibbs, J. Simon R. , McLaughlin, Vallerie V. , Gomberg-Maitland, Mardi , Kim, Samuel S. , Preston, Ioana R. , Ghofrani, H. Ardeschir

in Activin / Activins - antagonists & inhibitors / Activins - metabolism / Adult / Aged / Blood pressure / Body weight / Cardiac catheterization / Cardiology / Cardiology General / Clinical Medicine / Clinical Medicine General / Clinical significance / Clinical trials / Critical Care / Critical Care General / Death / Diagnosis / Disease Progression / Double-Blind Method / Drug Therapy, Combination - adverse effects / Drug Therapy, Combination - methods / Epistaxis - chemically induced / Epistaxis - epidemiology / Exercise Test / Female / Follow-Up Studies / Functional morphology / Heart / Hemodynamics / Hemoglobin / Hospitalization - statistics & numerical data / Humans / Hypertension / Hypertension, Pulmonary - diagnosis / Hypertension, Pulmonary - drug therapy / Hypertension, Pulmonary - mortality / Intubation / Kaplan-Meier Estimate / Lung transplantation / Male / Middle Aged / Morbidity / Outpatient-Based Clinical Medicine / Placebos / Pulmonary / Pulmonary Arterial Hypertension - drug therapy / Pulmonary Arterial Hypertension - mortality / Pulmonary Hypertension / Recombinant Fusion Proteins - administration & dosage / Recombinant Fusion Proteins - adverse effects / Telangiectasis - chemically induced / Telangiectasis - epidemiology / Treatment Outcome

2025

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Sotatercept for Pulmonary Arterial Hypertension within the First Year after Diagnosis

2025

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2025

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Journal Article

Sotatercept for Pulmonary Arterial Hypertension within the First Year after Diagnosis

Meyer, Gisela,

Brambatti, Michela,

Miller, Barry,

Koglin, Joerg,

Humbert, Marc,

Olsson, Karen M.,

Patel, Mahesh J.,

Shi, Yaru,

Badesch, David B.,

Waxman, Aaron B.,

Cornell, Alexandra G.,

Hoeper, Marius M.,

Kopeć, Grzegorz,

Mackenzie, Harald S.,

Souza, Rogerio,

Fu, Wei,

Gibbs, J. Simon R.,

McLaughlin, Vallerie V.,

Gomberg-Maitland, Mardi,

Kim, Samuel S.,

Preston, Ioana R.,

Ghofrani, H. Ardeschir

2025

Overview

Among adults with pulmonary arterial hypertension who had received the diagnosis less than 1 year earlier, the addition of sotatercept to background therapy resulted in a lower risk of clinical worsening than placebo.

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Publisher

Massachusetts Medical Society

Subject

Activin

/ Activins - antagonists & inhibitors

/ Activins - metabolism

/ Adult

/ Aged

/ Blood pressure

/ Body weight