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Novel dual gene fusions identified in a late pulmonary metastasis of an infantile fibrosarcoma-like tumor
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Novel dual gene fusions identified in a late pulmonary metastasis of an infantile fibrosarcoma-like tumor
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Journal Article
Novel dual gene fusions identified in a late pulmonary metastasis of an infantile fibrosarcoma-like tumor
2025
Overview
The list of potential gene fusions involving sarcomas, and particularly infantile fibrosarcoma-like tumors, continues to expand. The receptor tyrosine kinases are dysregulated in several tumor types, underscoring their roles in neoplasia. In this case presentation, we describe a pulmonary metastasis with two novel gene fusions (
FKBP5
::
PRKCA
and in-frame
SEPT7
::
RAF1
) occurring at least two decades after the primary tumor developed.
