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Effectiveness of doctors’ advice on non-prescription antibiotic use: a randomized controlled trial, China
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Effectiveness of doctors’ advice on non-prescription antibiotic use: a randomized controlled trial, China
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Journal Article
Effectiveness of doctors’ advice on non-prescription antibiotic use: a randomized controlled trial, China
2026
Overview
To evaluate a family doctor-led, community-based intervention to reduce non-prescription antibiotic use.
We conducted a parallel-group, cluster-randomized controlled trial at 22 community health centres in Shenzhen, China, over an 8-month period in 2023. We randomly (1 : 1) assigned community health centres to provide a 4-week, family doctor-led, community-based online health intervention, or to provide routine care only. Eligible participants were adults aged 18 to 75 years who had resided in the community for more than 6 months. The primary outcome was the level of non-prescription antibiotic use (including self-medication with antibiotics and purchase of antibiotics without a prescription). Secondary outcomes were: levels of self-medication with antibiotics; purchase of antibiotics without a prescription; self-storage of antibiotics; and prescribed antibiotic use.
We enrolled 1550 participants, with 788 assigned to the intervention group and 762 to the control group. We observed a significant decrease in non-prescription antibiotic use in the intervention group compared to the control group (odds ratio, OR: 0.49; 95% confidence interval, CI: 0.31-0.77) at 6 months. There was a significant reduction in self-medication (OR: 0.33; 95% CI: 0.13-0.83) and purchase of antibiotics without a prescription (OR: 0.59; 95% CI: 0.37-0.94), but not in self-storage (OR: 0.80; 95% CI: 0.54-1.18) or prescribed antibiotic use (OR: 0.94; 95% CI: 0.48-1.87) at 6 months.
The family doctor-led, community-based intervention demonstrated promising effectiveness and feasibility. This study provides valuable insights for the design and implementation of such interventions aimed at promoting rational use of antibiotics.
Publisher
World Health Organization
Subject
/ Adult
/ Adults
/ Aged
/ Anti-Bacterial Agents - therapeutic use
/ China
/ Drugs
/ Female
/ Groups
/ Health
/ Humans
/ Male
/ Multidrug resistant organisms
/ Nonprescription Drugs - therapeutic use
/ Practice Patterns, Physicians' - statistics & numerical data
/ Randomized Controlled Trials as Topic
/ Self Medication - statistics & numerical data
/ Storage
