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Prevention of type 1 diabetes through infection with an intestinal nematode parasite requires IL-10 in the absence of a Th2-type response
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Prevention of type 1 diabetes through infection with an intestinal nematode parasite requires IL-10 in the absence of a Th2-type response
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Journal Article
Prevention of type 1 diabetes through infection with an intestinal nematode parasite requires IL-10 in the absence of a Th2-type response
2013
Overview
Helminth infection can prevent type 1 diabetes (T1D); however, the regulatory mechanisms inhibiting disease remain largely undefined. In these studies, nonobese diabetic (NOD) IL-4−/− mice were infected with the strictly enteric nematode parasite, Heligmosomoides polygyrus. Short-term infection, 5–7 weeks of age, inhibited T1D onset, as late as 40 weeks of age. CD4+ T-cell STAT6 phosphorylation was inhibited, while suppressed signal transducer and activator of transcription 1 phosphorylation was sustained, as were increases in FOXP3−, CD4+ T-cell interleukin (IL)-10 production. Blockade of IL-10 signaling in NOD-IL-4−/−, but not in NOD, mice during this short interval abrogated protective effects resulting in pancreatic β-cell destruction and ultimately T1D. Transfer of CD4+ T cells from H. polygyrus (Hp)-inoculated NOD IL-4−/− mice to NOD mice blocked the onset of T1D. These studies indicate that Hp infection induces non-T-regulatory cells to produce IL-10 independently of STAT6 signaling and that in this Th2-deficient environment IL-10 is essential for T1D inhibition.
Publisher
Elsevier Inc,Nature Publishing Group US,Elsevier Limited
Subject
/ Animals
/ Biomedical and Life Sciences
/ CD4-Positive T-Lymphocytes - immunology
/ CD4-Positive T-Lymphocytes - metabolism
/ Diabetes Mellitus, Type 1 - immunology
/ Diabetes Mellitus, Type 1 - prevention & control
/ Female
/ Insulin-Secreting Cells - pathology
/ Interferon-gamma - immunology
/ Interferon-gamma - metabolism
/ Islets of Langerhans - immunology
/ Lymphoid Tissue - immunology
/ Lymphoid Tissue - metabolism
/ Mice
/ Nematospiroides dubius - immunology
/ Receptors, Interleukin-10 - antagonists & inhibitors
/ STAT1 Transcription Factor - metabolism
/ STAT6 Transcription Factor - metabolism
