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Nd3+ Sensitized Up/Down Converting Dual-Mode Nanomaterials for Efficient In-vitro and In-vivo Bioimaging Excited at 800 nm
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Nd3+ Sensitized Up/Down Converting Dual-Mode Nanomaterials for Efficient In-vitro and In-vivo Bioimaging Excited at 800 nm
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Journal Article
Nd3+ Sensitized Up/Down Converting Dual-Mode Nanomaterials for Efficient In-vitro and In-vivo Bioimaging Excited at 800 nm
2013
Overview
Core/shell1/shell2/shell3 structured NaGdF
4
:Nd/NaYF
4
/NaGdF
4
:Nd,Yb,Er/NaYF
4
nanocrystals were well designed and synthesized, each of the parts assume respective role and work together to achieve dual-mode upconverting (UC) and downconverting (DC) luminescence upon the low heat effect 800-nm excitation. Nd
3+
, Yb
3+
, Er
3+
tri-doped NaGdF
4
:Nd,Yb,Er UC layer [NIR (800 nm)-to-Visible (540 nm)] with a constitutional efficient 800 nm excitable property were achieved for the
in-vitro
bioimaging with low auto-fluorescence and photo-damage effects. Moreover, typical NIR (800 nm)-to-NIR (860–895 nm) DC luminescence of Nd
3+
has also been realized with this designed nanostructure. Due to the low heat effect, high penetration depth of the excitation and the high efficiency of the DC luminescence, the
in-vivo
high contrast DC imaging of a whole body nude mouse was achieved. We believe that such dual-mode luminescence NCs will open the door to engineering the excitation and emission wavelengths of NCs and will provide a new tool for a wide variety of applications in the fields of bioanalysis and biomedical.
Publisher
Nature Publishing Group UK,Nature Publishing Group
