Asset Details
Do you wish to reserve the book?
Assessment of pathological response to therapy using lipid mass spectrometry imaging
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Assessment of pathological response to therapy using lipid mass spectrometry imaging
Do you wish to request the book?
Assessment of pathological response to therapy using lipid mass spectrometry imaging
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Assessment of pathological response to therapy using lipid mass spectrometry imaging
2016
Overview
In many cancers, the establishment of a patient’s future treatment regime often relies on histopathological assessment of tumor tissue specimens in order to determine the extent of the ‘pathological response’ to a given therapy. However, histopathological assessment of pathological response remains subjective. Here we use MALDI mass spectrometry imaging to generate lipid signatures from colorectal cancer liver metastasis specimens resected from patients preoperatively treated with chemotherapy. Using these signatures we obtained a unique pathological response score that correlates with prognosis. In addition, we identify single lipid moieties that are overexpressed in different histopathological features of the tumor, which have potential as new biomarkers for assessing response to therapy. These data show that computational methods, focusing on the lipidome, can be used to determine prognostic markers for response to chemotherapy and may potentially improve risk assessment and patient care.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Adult
/ Aged
/ Biomarkers, Tumor - analysis
/ Chemotherapy, Adjuvant - methods
/ Colorectal Neoplasms - diagnostic imaging
/ Colorectal Neoplasms - drug therapy
/ Colorectal Neoplasms - metabolism
/ Colorectal Neoplasms - pathology
/ Female
/ Humanities and Social Sciences
/ Humans
/ Lipids
/ Liver
/ Liver Neoplasms - diagnostic imaging
/ Liver Neoplasms - drug therapy
/ Liver Neoplasms - metabolism
/ Male
/ Science
/ Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
/ Toxicity
