Journal Article

Cicada-inspired cell-instructive nanopatterned arrays

Faruqui, Nilofar, Diu, Ting, Su, Bo, Sjöström, Terje, Jenkinson, Howard F., Ryadnov, Maxim G., Lamarre, Baptiste

2014

Overview

Biocompatible surfaces hold key to a variety of biomedical problems that are directly related to the competition between host-tissue cell integration and bacterial colonisation. A saving solution to this is seen in the ability of cells to uniquely respond to physical cues on such surfaces thus prompting the search for cell-instructive nanoscale patterns. Here we introduce a generic rationale engineered into biocompatible, titanium, substrates to differentiate cell responses. The rationale is inspired by cicada wing surfaces that display bactericidal nanopillar patterns. The surfaces engineered in this study are titania (TiO 2 ) nanowire arrays that are selectively bactericidal against motile bacteria, while capable of guiding mammalian cell proliferation according to the type of the array. The concept holds promise for clinically relevant materials capable of differential physico-mechanical responses to cellular adhesion.

• Publisher: Nature Publishing Group UK,Nature Publishing Group
• Subject: 13/107 / 14 / 14/19 / 147/135 / 631/57/2282 / 639/301/54/989 / Animals / Anti-Bacterial Agents - pharmacology / Antimicrobial agents / Arrays / Bacillus subtilis - drug effects / Bacillus subtilis - growth & development / Bacteria / Biocompatible Materials - chemistry / Biocompatible Materials - pharmacology / Biomimetic Materials - chemistry / Biomimetic Materials - pharmacology / Cell adhesion & migration / Cell Adhesion - drug effects / Cell growth / Cell Line, Tumor / Cell proliferation / Cell Proliferation - drug effects / Cell Survival - drug effects / Drug resistance / Escherichia coli - drug effects / Escherichia coli - growth & development / Hemiptera - anatomy & histology / Humanities and Social Sciences / Humans / Integration / Motility / multidisciplinary / Nanotechnology / Nanowires / Orthopedics / Osteoblasts - cytology / Osteoblasts - drug effects / Pseudomonas aeruginosa - drug effects / Pseudomonas aeruginosa - growth & development / Science / Staphylococcus aureus - drug effects / Staphylococcus aureus - growth & development / Surface Properties / Tissue Engineering / Tissue Scaffolds / Titanium / Titanium - chemistry / Titanium - pharmacology / Titanium dioxide / Transplants & implants / Wings, Animal - anatomy & histology