Journal Article

Loss of Transient Receptor Potential Ankyrin 1 Channel Deregulates Emotion, Learning and Memory, Cognition, and Social Behavior in Mice

Lee, Kuan-I, Lee, Tzong-Shyuan, Lee, Hsueh-Te, Tsai, Feng-Chuan, Lin, Hui-Ching

2017

Overview

The transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel that helps regulate inflammatory pain sensation and nociception and the development of inflammatory diseases. However, the potential role of the TRPA1 channel and the underlying mechanism in brain functions are not fully resolved. In this study, we demonstrated that genetic deletion of the TRPA1 channel in mice or pharmacological inhibition of its activity increased neurite outgrowth. In vivo study in mice provided evidence of the TRPA1 channel as a negative regulator in hippocampal functions; functional ablation of the TRPA1 channel in mice enhanced hippocampal functions, as evidenced by less anxiety-like behavior, and enhanced fear-related or spatial learning and memory, and novel location recognition as well as social interactions. However, the TRPA1 channel appears to be a prerequisite for motor function; functional loss of the TRPA1 channel in mice led to axonal bundle fragmentation, downregulation of myelin basic protein, and decreased mature oligodendrocyte population in the brain, for impaired motor function. The TRPA1 channel may play a crucial role in neuronal development and oligodendrocyte maturation and be a potential regulator in emotion, cognition, learning and memory, and social behavior.

• Publisher: Springer US,Springer Nature B.V
• Subject: Amygdala - metabolism / Animal behavior / Animals / Ankyrins / Anxiety / Anxiety - metabolism / Axonogenesis / Axons - drug effects / Axons - metabolism / Behavior, Animal / Biomedical and Life Sciences / Biomedicine / Cell Biology / Cell Differentiation - drug effects / Cell Line / Clonal deletion / Cognition / Cognition & reasoning / Cognition - drug effects / Emotions / Emotions - drug effects / Fear / Gene Deletion / Hippocampus / Hippocampus - metabolism / Inflammatory diseases / Learning / Male / Maturation / Memory / Memory - drug effects / Mice / Motor Activity - drug effects / Motor task performance / Myelin / Myelin basic protein / Myelin Sheath - metabolism / Neurites - drug effects / Neurites - metabolism / Neurobiology / Neurology / Neurons / Neurosciences / Oligodendroglia - drug effects / Oligodendroglia - metabolism / Pain perception / Rodents / Social Behavior / Social discrimination learning / Social interactions / Spatial discrimination / Spatial discrimination learning / Spatial memory / Transient receptor potential proteins / Tretinoin - pharmacology / TRPA1 Cation Channel - deficiency / TRPA1 Cation Channel - metabolism