Asset Details
Do you wish to reserve the book?
UGP2 is a potential target for breast cancer, based on bioinformatics analysis and in vitro experiments
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
UGP2 is a potential target for breast cancer, based on bioinformatics analysis and in vitro experiments
Do you wish to request the book?
UGP2 is a potential target for breast cancer, based on bioinformatics analysis and in vitro experiments
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
UGP2 is a potential target for breast cancer, based on bioinformatics analysis and in vitro experiments
2025
Overview
Breast cancer represents the most prevalent malignancy in women globally. While UDP-glucose pyrophosphorylase 2 (UGP2) has been implicated in tumor biology, its pathophysiological role in breast carcinogenesis remains undefined. This study systematically investigates the clinical relevance and functional mechanisms of UGP2 in breast cancer progression. Multi-omics analysis was conducted using GEPIA2, TIMER2, and TCGA databases to evaluate UGP2 expression patterns, clinicopathological correlations, and prognostic significance across breast cancer subtypes. Findings were validated through immunohistochemical analysis of 118 clinical specimens. Single-cell RNA sequencing data from GEO were employed to resolve UGP2 spatial distribution within tumor microenvironments. Functional enrichment analysis elucidated UGP2-associated pathways, while loss-of-function experiments using siRNA-mediated knockdown assessed UGP2’s impact on malignant phenotypes in breast cancer cell lines. Our research found that the expression level of UGP2 in the TNBC subtype was significantly higher than that in other subtypes. The elevated expression level of UGP2 suggests a poor prognosis for breast cancer patients. The high expression level of UGP2 is positively correlated with the level of CNV. UGP2 is mainly located in epithelial cells and CAFs subsets and can participate in biological processes such as collagen synthesis. Knockdown of UGP2 in vitro can inhibit the proliferation, migration and invasion abilities of breast cancer cells. This study demonstrates that elevated UGP2 expression is clinically associated with aggressive tumor behavior and unfavorable prognosis in breast cancer patients, particularly in the triple-negative subtype (TNBC). Mechanistic analyses reveal UGP2’s functional involvement in both tumor cell proliferation and stromal remodeling through cancer-associated fibroblast (CAF) interactions. The robust association between UGP2 overexpression and aggressive clinicopathological features positions it as both a promising prognostic biomarker and potential therapeutic target, particularly in TNBC management.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/80
/ Biomarkers, Tumor - genetics
/ Biomarkers, Tumor - metabolism
/ Breast Neoplasms - metabolism
/ Breast Neoplasms - pathology
/ Cancer-associated fibroblasts (CAFs)
/ Computational Biology - methods
/ Enzymes
/ Female
/ Gene Expression Regulation, Neoplastic
/ Gene set enrichment analysis
/ Glucose
/ Humanities and Social Sciences
/ Humans
/ Proteins
/ Science
/ siRNA
/ Triple Negative Breast Neoplasms - genetics
/ Triple Negative Breast Neoplasms - pathology
/ Tumors
/ UGP2
