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Expression of cytochrome P450 monooxygenase genes in pyrethroid-resistant Aedes albopictus
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Expression of cytochrome P450 monooxygenase genes in pyrethroid-resistant Aedes albopictus
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Journal Article
Expression of cytochrome P450 monooxygenase genes in pyrethroid-resistant Aedes albopictus
2025
Overview
Control of dengue vectors with synthetic pyrethroids is employed worldwide but development of pyrethroid resistance in
Aedes
mosquitoes is a big challenge for successful prevention of dengue. Pyrethroids are of two types: type I (devoid of α-cyano group) and type II (contain α-cyano group) which differ in their toxic effect. Therefore, this study investigated potential difference in the cytochrome P450 monooxygenase (CYP) mediated resistance status against two types of synthetic pyrethroids in wild
Aedes
(
Ae.
)
albopictus
populations from dengue endemic sub-Himalayan West Bengal. The role of CYPs in resistance development was studied through synergist assay and gene expression studies. Widespread resistance was observed against permethrin (type I) and lambdacyhalothrin (type II) in studied populations. Use of Piperonyl Butoxide (PBO) in synergist assay restored susceptibility to both the insecticides and confirmed involvement of CYP in observed resistance. Differential overexpression of three CYP genes,
CYP6P12
,
CYP6A8
and
CYP6N3
was observed in all populations and population specific differential induction of
CYP6P12
and
CYP6A8
upon permethrin and lambdacyhalothrin exposure was also noted. These findings indicate occurrence of monooxygenase mediated pyrethroid resistance in
Ae. albopictus
populations from this region. Use of monooxygenase blockers can improve the efficacy of pyrethroids for control of this vector.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/337
/ 631/601
/ Adults
/ Aedes
/ Animals
/ Cytochrome P-450 Enzyme System - genetics
/ Cytochrome P-450 Enzyme System - metabolism
/ Cytochrome P450 monooxygenase
/ Enzymes
/ Humanities and Social Sciences
/ Insecticide Resistance - genetics
/ Mosquito Vectors - drug effects
/ Mutation
/ Piperonyl Butoxide - pharmacology
/ Science
/ Toxicity
/ Vectors
