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Membrane Driven Spatial Organization of GPCRs
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Journal Article
Membrane Driven Spatial Organization of GPCRs
2013
Overview
Spatial organization of G-protein coupled receptors (GPCRs) into dimers and higher order oligomers has been demonstrated
in vitro
and
in vivo
. The pharmacological readout was shown to depend on the specific interfaces, but why particular regions of the GPCR structure are involved and how ligand-determined states change them remains unknown. Here we show why protein-membrane hydrophobic matching is attained upon oligomerization at specific interfaces from an analysis of coarse-grained molecular dynamics simulations of the spontaneous diffusion-interaction of the prototypical beta2-adrenergic (β
2
AR) receptors in a POPC lipid bilayer. The energy penalty from mismatch is significantly reduced in the spontaneously emerging oligomeric arrays, making the spatial organization of the GPCRs dependent on the pattern of mismatch in the monomer. This mismatch pattern is very different for β
2
AR compared to the highly homologous and structurally similar β
1
AR, consonant with experimentally observed oligomerization patterns of β
2
AR and β
1
AR. The results provide a mechanistic understanding of the structural context of oligomerization.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Arrays
/ Energy
/ Humanities and Social Sciences
/ Humans
/ Hydrophobic and Hydrophilic Interactions
/ Ligands
/ Lipids
/ Molecular Dynamics Simulation
/ Phosphatidylcholines - chemistry
/ Proteins
/ Receptors, Adrenergic, beta-1 - chemistry
/ Receptors, Adrenergic, beta-2 - chemistry
/ Science
