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Oxoaporphine Metal Complexes (CoII, NiII, ZnII) with High Antitumor Activity by Inducing Mitochondria-Mediated Apoptosis and S-phase Arrest in HepG2
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Oxoaporphine Metal Complexes (CoII, NiII, ZnII) with High Antitumor Activity by Inducing Mitochondria-Mediated Apoptosis and S-phase Arrest in HepG2
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Oxoaporphine Metal Complexes (CoII, NiII, ZnII) with High Antitumor Activity by Inducing Mitochondria-Mediated Apoptosis and S-phase Arrest in HepG2
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Journal Article
Oxoaporphine Metal Complexes (CoII, NiII, ZnII) with High Antitumor Activity by Inducing Mitochondria-Mediated Apoptosis and S-phase Arrest in HepG2
2017
Overview
Three new oxoaporphine Co(II), Ni(II) and Zn(II) complexes
1
–
3
have been synthesized and fully characterized.
1
–
3
have similar mononuclear structures with the metal and ligand ratio of 1:2.
1
–
3
exhibited higher cytotoxicity than the
OD
ligand and cisplatin against HepG2, T-24, BEL-7404, MGC80–3 and SK-OV-3/DDP cells, with IC
50
value of 0.23−4.31 μM. Interestingly, 0.5 μM
1
–
3
significantly caused HepG2 arrest at S-phase, which was associated with the up-regulation of p53, p21, p27, Chk1 and Chk2 proteins, and decrease in cyclin A, CDK2, Cdc25A, PCNA proteins. In addition,
1
–
3
induced HepG2 apoptosis via a caspase-dependent mitochondrion pathway as evidenced by p53 activation, ROS production, Bax up-regulation and Bcl-2 down-regulation, mitochondrial dysfunction, cytochrome
c
release, caspase activation and PARP cleavage. Furthermore,
3
inhibited tumor growth in HepG2 xenograft model, and displayed more safety profile
in vivo
than cisplatin.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/31
/ 14
/ 14/19
/ 82/80
/ Animals
/ Antineoplastic Agents - chemical synthesis
/ Antineoplastic Agents - chemistry
/ Antineoplastic Agents - pharmacology
/ Aporphines - chemical synthesis
/ Caspase
/ Cell Cycle Checkpoints - drug effects
/ Coordination Complexes - chemical synthesis
/ Coordination Complexes - chemistry
/ Coordination Complexes - pharmacology
/ Cyclin A
/ DNA Topoisomerases, Type II - metabolism
/ Down-Regulation - drug effects
/ Humanities and Social Sciences
/ Humans
/ Ligands
/ Membrane Potential, Mitochondrial - drug effects
/ Mice
/ Nickel
/ Proliferating cell nuclear antigen
/ Reactive Oxygen Species - metabolism
/ Science
/ Signal Transduction - drug effects
/ Tumor Suppressor Protein p53 - metabolism
/ Up-Regulation - drug effects
