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Gallic acid/hydroxypropyl-β-cyclodextrin complex: Improving solubility for application on in vitro/ in vivo Candida albicans biofilms
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Gallic acid/hydroxypropyl-β-cyclodextrin complex: Improving solubility for application on in vitro/ in vivo Candida albicans biofilms
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Journal Article
Gallic acid/hydroxypropyl-β-cyclodextrin complex: Improving solubility for application on in vitro/ in vivo Candida albicans biofilms
2017
Overview
The aim of this study was to increase the solubility of gallic acid (GA) for the treatment of Candida albicans biofilm, which is very difficult to treat and requires high drug concentrations. Cyclodextrins (CDs) were used for this purpose. Complexes were evaluated by phase-solubility studies, prepared by spray drying and characterized by drug loading, scanning electron microscopy (SEM) and differential scanning calorimetry (DSC). The complexes were tested on C. albicans biofilm using in vitro and in vivo models. HPβCD formed soluble inclusion complexes with GA. The percentage of GA in GA/HPβCD was 10.8 ± 0.01%. The SEM and DSC analyses confirmed the formation of inclusion complexes. GA/HPβCD maintained the antimicrobial activity of the pure GA. GA/HPβCD was effective on C. albicans biofilms of 24 and 48h. The in vivo results showed an anti-inflammatory activity of GA/HPβCD with no difference in invading hypha counting among the groups. This study encourages the development of new antifungal agents.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
2-Hydroxypropyl-beta-cyclodextrin
/ Antiinfectives and antibacterials
/ beta-Cyclodextrins - chemistry
/ Biofilms
/ Cadmium
/ Calorimetry, Differential Scanning
/ Candida albicans - drug effects
/ Candida albicans - ultrastructure
/ Differential scanning calorimetry
/ Drying
/ Medicine and Health Sciences
/ Microscopy, Electron, Scanning
/ Research and Analysis Methods
/ Scanning electron microscopy
/ Science
