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Current Approaches in Hepatoblastoma—New Biological Insights to Inform Therapy
by
Rangaswami, Arun
, Wu, Peng V.
in
Abdomen
/ Age
/ Animal models
/ Biology
/ Birth defects
/ Birth weight
/ Cancer therapies
/ Cell culture
/ Chemotherapy
/ Cisplatin
/ Congenital diseases
/ Genomics
/ Hematology
/ Histology
/ Immunotherapy
/ Liver cancer
/ Medical prognosis
/ Medicine
/ Medicine & Public Health
/ Metastases
/ Metastasis
/ Oncology
/ Pediatric Oncology (KL Davis
/ Pediatrics
/ Section Editor
/ Topical Collection on Pediatric Oncology
/ Toxicity
/ Transcriptomics
/ Tumorigenesis
/ Tumors
/ Wnt protein
/ β-Catenin
2022
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Current Approaches in Hepatoblastoma—New Biological Insights to Inform Therapy
by
Rangaswami, Arun
, Wu, Peng V.
in
Abdomen
/ Age
/ Animal models
/ Biology
/ Birth defects
/ Birth weight
/ Cancer therapies
/ Cell culture
/ Chemotherapy
/ Cisplatin
/ Congenital diseases
/ Genomics
/ Hematology
/ Histology
/ Immunotherapy
/ Liver cancer
/ Medical prognosis
/ Medicine
/ Medicine & Public Health
/ Metastases
/ Metastasis
/ Oncology
/ Pediatric Oncology (KL Davis
/ Pediatrics
/ Section Editor
/ Topical Collection on Pediatric Oncology
/ Toxicity
/ Transcriptomics
/ Tumorigenesis
/ Tumors
/ Wnt protein
/ β-Catenin
2022
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While trying to remove the title from your shelf something went wrong :( Kindly try again later!
Do you wish to request the book?
Current Approaches in Hepatoblastoma—New Biological Insights to Inform Therapy
by
Rangaswami, Arun
, Wu, Peng V.
in
Abdomen
/ Age
/ Animal models
/ Biology
/ Birth defects
/ Birth weight
/ Cancer therapies
/ Cell culture
/ Chemotherapy
/ Cisplatin
/ Congenital diseases
/ Genomics
/ Hematology
/ Histology
/ Immunotherapy
/ Liver cancer
/ Medical prognosis
/ Medicine
/ Medicine & Public Health
/ Metastases
/ Metastasis
/ Oncology
/ Pediatric Oncology (KL Davis
/ Pediatrics
/ Section Editor
/ Topical Collection on Pediatric Oncology
/ Toxicity
/ Transcriptomics
/ Tumorigenesis
/ Tumors
/ Wnt protein
/ β-Catenin
2022
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Current Approaches in Hepatoblastoma—New Biological Insights to Inform Therapy
Journal Article
Current Approaches in Hepatoblastoma—New Biological Insights to Inform Therapy
2022
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Overview
Purpose of Review
As the most common pediatric primary liver cancer with rising incidence, hepatoblastoma remains challenging to treat. Here, we review the current understanding of the biology of hepatoblastoma and discuss how recent advances may lead to new treatment modalities.
Recent Findings
Standard chemotherapy regimens including cisplatin, in addition to surgery, have led to high cure rates among patients with low stage hepatoblastoma; however, metastatic and relapsed disease continue to have poor outcomes. Recent genomics and functional studies in cell lines and mouse models have established a central role for the Wnt/β-catenin pathway in tumorigenesis. Targeted agents and immunotherapy approaches are emerging as potential treatment avenues.
Summary
With recent gains in knowledge of the genomic and transcriptomic landscape of hepatoblastoma, new therapeutic mechanisms can now be explored to improve outcomes for metastatic and relapsed hepatoblastoma and to reduce the toxicity of current treatments.
Publisher
Springer US,Springer Nature B.V
Subject
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