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Stimulation of neural stem cell differentiation by circularly polarized light transduced by chiral nanoassemblies
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Stimulation of neural stem cell differentiation by circularly polarized light transduced by chiral nanoassemblies
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Journal Article
Stimulation of neural stem cell differentiation by circularly polarized light transduced by chiral nanoassemblies
2021
Overview
The biological effects of circularly polarized light on living cells are considered to be negligibly weak. Here, we show that the differentiation of neural stem cells into neurons can be accelerated by circularly polarized photons when DNA-bridged chiral assemblies of gold nanoparticles are entangled with the cells’ cytoskeletal fibres. By using cell-culture experiments and plasmonic-force calculations, we demonstrate that the nanoparticle assemblies exert a circularly-polarized-light-dependent force on the cytoskeleton, and that the light-induced periodic mechanical deformation of actin nanofibres with a frequency of 50 Hz stimulates the differentiation of neural stem cells into the neuronal phenotype. When implanted in the hippocampus of a mouse model of Alzheimer’s disease, neural stem cells illuminated following a polarity-optimized protocol reduced the formation of amyloid plaques by more than 70%. Our findings suggest that circularly polarized light can guide cellular development for biomedical use.
Chiral photons can accelerate the differentiation of neural stem cells into neurons in vitro and in vivo when DNA-bridged chiral assemblies of gold nanoparticles are tightly entangled with the cells’ cytoskeletal fibres.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 631/57
/ 639/301
/ 639/624
/ 639/925
/ 64
/ 64/60
/ 82
/ Actin
/ Animals
/ Biomedical and Life Sciences
/ Biomedical Engineering/Biotechnology
/ Cell Differentiation - drug effects
/ Cell Differentiation - radiation effects
/ Cytoskeleton - radiation effects
/ DNA
/ Fibers
/ Gold
/ Humans
/ Metal Nanoparticles - chemistry
/ Mice
/ Neural Stem Cells - cytology
/ Neural Stem Cells - drug effects
/ Neural Stem Cells - radiation effects
/ Neurons
/ Photons
/ Polarity
