Asset Details
Do you wish to reserve the book?
Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation
Do you wish to request the book?
Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation
2013
Overview
Induction of antigen-specific CD8
+
T cells offers the prospect of immunization against many infectious diseases, but no subunit vaccine has induced CD8
+
T cells that correlate with efficacy in humans. Here we demonstrate that a replication-deficient chimpanzee adenovirus vector followed by a modified vaccinia virus Ankara booster induces exceptionally high frequency T-cell responses (median >2400 SFC/10
6
peripheral blood mononuclear cells) to the liver-stage
Plasmodium falciparum
malaria antigen ME-TRAP. It induces sterile protective efficacy against heterologous strain sporozoites in three vaccinees (3/14, 21%), and delays time to patency through substantial reduction of liver-stage parasite burden in five more (5/14, 36%),
P
=0.008 compared with controls. The frequency of monofunctional interferon-γ-producing CD8
+
T cells, but not antibodies, correlates with sterile protection and delay in time to patency (
P
corrected
=0.005). Vaccine-induced CD8
+
T cells provide protection against human malaria, suggesting that a major limitation of previous vaccination approaches has been the insufficient magnitude of induced T cells.
Induction of protective immunity mediated by CD8
+
T cells has been a long sought goal in vaccinology. Here, Ewer
et al.
report induction of protective efficacy against
Plasmodium falciparum
malaria in a phase IIa prime-boost vaccine trial where efficacy correlates strongly with induced CD8 T-cell responses.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Pub. Group
Subject
/ 13/21
/ 13/31
/ 692/308
/ Adenoviruses, Simian - genetics
/ Adenoviruses, Simian - immunology
/ Adult
/ Animals
/ Antibodies, Protozoan - immunology
/ Antigens
/ CD8-Positive T-Lymphocytes - immunology
/ Cells
/ Female
/ Genetic Vectors - immunology
/ Humanities and Social Sciences
/ Humans
/ Interferon-gamma - immunology
/ Liver
/ Malaria
/ Malaria Vaccines - administration & dosage
/ Malaria Vaccines - immunology
/ Malaria, Falciparum - immunology
/ Malaria, Falciparum - parasitology
/ Malaria, Falciparum - prevention & control
/ Male
/ Plasmodium falciparum - genetics
/ Plasmodium falciparum - immunology
/ Protozoan Proteins - genetics
/ Protozoan Proteins - immunology
/ Science
/ Vaccines
We currently cannot retrieve any items related to this title. Kindly check back at a later time.