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A physiologic comparison of proportional assist ventilation with load-adjustable gain factors (PAV+) versus pressure support ventilation (PSV)
A physiologic comparison of proportional assist ventilation with load-adjustable gain factors (PAV+) versus pressure support ventilation (PSV)
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A physiologic comparison of proportional assist ventilation with load-adjustable gain factors (PAV+) versus pressure support ventilation (PSV)
A physiologic comparison of proportional assist ventilation with load-adjustable gain factors (PAV+) versus pressure support ventilation (PSV)

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A physiologic comparison of proportional assist ventilation with load-adjustable gain factors (PAV+) versus pressure support ventilation (PSV)
A physiologic comparison of proportional assist ventilation with load-adjustable gain factors (PAV+) versus pressure support ventilation (PSV)
Journal Article

A physiologic comparison of proportional assist ventilation with load-adjustable gain factors (PAV+) versus pressure support ventilation (PSV)

2011
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Overview
Purpose To compare patient–ventilator interaction during PSV and PAV+ in patients that are difficult to wean. Methods This was a physiologic study involving 11 patients. During three consecutive trials (PSV first trial—PSV1, followed by PAV+, followed by a second PSV trial—PSV2, with the same settings as PSV1) we evaluated mechanical and patient respiratory pattern; inspiratory effort from excursion Pdi (swing Pdi ), and pressure–time products of the transdiaphragmatic (PTPdi) pressures. Inspiratory (delay trinsp ) and expiratory (delay trexp ) trigger delays, time of synchrony (time syn ), and asynchrony index (AI) were assessed. Results Compared to PAV+, during PSV trials, the mechanical inspiratory time (Ti flow ) was significantly longer than patient inspiratory time (Ti pat ) ( p  < 0.05); Ti pat showed a prolongation between PSV1 and PAV+, significant comparing PAV+ and PSV2 ( p  < 0.05). PAV+ significantly reduced delay trexp ( p  < 0.001). The portion of tidal volume (VT) delivered in phase with Ti pat (VT pat /VT mecc ) was significantly higher during PAV+ ( p  < 0.01). The time of synchrony was significantly longer during PAV+ than during PSV ( p  < 0.001). During PSV 5 patients out of 11 showed an AI greater than 10%, whereas the AI was nil during PAV+. Conclusion PAV+ improves patient–ventilator interaction, significantly reducing the incidence of end-expiratory asynchrony and increasing the time of synchrony.