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Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

by Leung, Mimi , Boyer, Michael , Bader, Peter , Martin, Paul L , Myers, Gary D , Davis, Kara L , Verneris, Michael R , Hiramatsu, Hidefumi , Zhang, Yiyun , Laetsch, Theodore W , Buechner, Jochen , Baruchel, Andre , Peters, Christina , Qayed, Muna , Maude, Shannon L , Rives, Susana , Krueger, Joerg , Mechinaud, Francoise , Nemecek, Eneida R , Yanik, Gregory A , Sen, Kapildeb , Pulsipher, Michael A , Levine, Bruce L , Lebwohl, David , Schlis, Krysta , Grupp, Stephan A , Bittencourt, Henrique , De Moerloose, Barbara , Stefanski, Heather E , Taran, Tetiana , Boissel, Nicolas , June, Carl H , Mueller, Karen T , Balduzzi, Adriana , Wood, Patricia

in Acute lymphoblastic leukemia / Adolescent / Antibodies, Monoclonal, Humanized - administration & dosage / Antigens, CD19 / Antineoplastic Combined Chemotherapy Protocols - therapeutic use / Bone marrow / Cancer / CD19 antigen / Child / Child, Preschool / Children / Children & youth / Chimeric antigen receptors / Edema / Female / Flow cytometry / Hematology / Humans / Infusions, Intravenous / Leukemia / Lymphatic leukemia / Lymphocytes B / Lymphocytes T / Male / Medical research / Minimal residual disease / Monoclonal antibodies / Oncology / Pediatrics / Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy / Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality / Receptors, Antigen, T-Cell - antagonists & inhibitors / Receptors, Antigen, T-Cell - therapeutic use / Remission / Remission Induction / Stem cells / Survival Analysis / Transplants & implants / Young Adult / Young adults

2018

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Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

2018

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Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

2018

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Journal Article

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

Leung, Mimi,

Boyer, Michael,

Bader, Peter,

Martin, Paul L,

Myers, Gary D,

Davis, Kara L,

Verneris, Michael R,

Hiramatsu, Hidefumi,

Zhang, Yiyun,

Laetsch, Theodore W,

Buechner, Jochen,

Baruchel, Andre,

Peters, Christina,

Qayed, Muna,

Maude, Shannon L,

Rives, Susana,

Krueger, Joerg,

Mechinaud, Francoise,

Nemecek, Eneida R,

Yanik, Gregory A,

Sen, Kapildeb,

Pulsipher, Michael A,

Levine, Bruce L,

Lebwohl, David,

Schlis, Krysta,

Grupp, Stephan A,

Bittencourt, Henrique,

De Moerloose, Barbara,

Stefanski, Heather E,

Taran, Tetiana,

Boissel, Nicolas,

June, Carl H,

Mueller, Karen T,

Balduzzi, Adriana,

Wood, Patricia

2018

Overview

CD19-specific CAR T cells were produced centrally for a global study in young people with relapsed B-cell ALL. The overall remission rate was 81%, and patients with a response were negative for minimal residual disease. High-grade toxic effects were frequent but treatable.

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Publisher

Massachusetts Medical Society

Subject

Acute lymphoblastic leukemia

/ Adolescent

/ Antibodies, Monoclonal, Humanized - administration & dosage

/ Antigens, CD19

/ Antineoplastic Combined Chemotherapy Protocols - therapeutic use

/ Bone marrow

/ Cancer