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Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy

by Parker, Christopher C , Russell, J. Martin , Robinson, Angus , Millman, Robin , Parmar, Mahesh K.B , Clarke, Noel W , Adab, Fawzi , Brock, Susannah , Birtle, Alison J , Thomas, Carys , Chowdhury, Simon , Brawley, Chris , James, Nicholas D , Protheroe, Andrew , O’Sullivan, Joe , de Bono, Johann S , Matheson, David , Hingorani, Mohan , Gale, Joanna , Hoskin, Peter J , Wylie, James , Bowen, Jo , Gilson, Clare , McKinna, Fiona , Zarkar, Anjali , Gray, Emma , Amos, Claire L , Aung, San , Attard, Gerhardt , Srihari, Narayanan N , Sydes, Matthew R , Dearnaley, David P , Cross, William R , Berthold, Dominik R , Ferguson, Catherine , Lester, Jason F , Spears, Melissa R , Ritchie, Alastair W.S , McPhail, Neil , Money-Kyrle, Julian , Jones, Rob J , Mason, Malcolm D , Gillessen, Silke , Malik, Zafar I , Chakraborti, Prabir , Parikh, Omi , Wagstaff, John

in Abiraterone Acetate - administration & dosage / Abiraterone Acetate - adverse effects / Adult / Aged / Aged, 80 and over / Androgen Antagonists - administration & dosage / Androgen Antagonists - adverse effects / Androgens / Antineoplastic Combined Chemotherapy Protocols - adverse effects / Antineoplastic Combined Chemotherapy Protocols - therapeutic use / Cancer therapies / Clinical trials / Death / Endocrine therapy / Hormone replacement therapy / Humans / Male / Medical prognosis / Medical research / Mens health / Metastases / Metastasis / Middle Aged / Neoplasm Metastasis - drug therapy / Neoplasm Recurrence, Local - drug therapy / Oncology / Prednisolone / Prednisolone - administration & dosage / Prednisolone - adverse effects / Prostate cancer / Prostate-specific antigen / Prostate-Specific Antigen - blood / Prostatic Neoplasms - drug therapy / Prostatic Neoplasms - mortality / Prostatic Neoplasms - radiotherapy / Prostatic Neoplasms - surgery / Radiation therapy / Steroid 17-alpha-Hydroxylase - antagonists & inhibitors / Survival Analysis

2017

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2017

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2017

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Journal Article

Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy

Parker, Christopher C,

Russell, J. Martin,

Robinson, Angus,

Millman, Robin,

Parmar, Mahesh K.B,

Clarke, Noel W,

Adab, Fawzi,

Brock, Susannah,

Birtle, Alison J,

Thomas, Carys,

Chowdhury, Simon,

Brawley, Chris,

James, Nicholas D,

Protheroe, Andrew,

O’Sullivan, Joe,

de Bono, Johann S,

Matheson, David,

Hingorani, Mohan,

Gale, Joanna,

Hoskin, Peter J,

Wylie, James,

Bowen, Jo,

Gilson, Clare,

McKinna, Fiona,

Zarkar, Anjali,

Gray, Emma,

Amos, Claire L,

Aung, San,

Attard, Gerhardt,

Srihari, Narayanan N,

Sydes, Matthew R,

Dearnaley, David P,

Cross, William R,

Berthold, Dominik R,

Ferguson, Catherine,

Lester, Jason F,

Spears, Melissa R,

Ritchie, Alastair W.S,

McPhail, Neil,

Money-Kyrle, Julian,

Jones, Rob J,

Mason, Malcolm D,

Gillessen, Silke,

Malik, Zafar I,

Chakraborti, Prabir,

Parikh, Omi,

Wagstaff, John

2017

Overview

The addition of abiraterone and prednisolone to standard androgen-deprivation therapy as the first treatment for patients with locally advanced or metastatic prostate cancer improved overall and failure-free survival, with a small increase in high-grade toxic effects.

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Publisher

Massachusetts Medical Society

Subject

Abiraterone Acetate - administration & dosage

/ Abiraterone Acetate - adverse effects

/ Adult

/ Aged

/ Aged, 80 and over

/ Androgen Antagonists - administration & dosage

/ Androgen Antagonists - adverse effects