Journal Article

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Ogishi, Masato, Ciznar, Peter, Belot, Alexandre, Kuehn, Hye Sun, Kenney, Heather, Latour, Sylvain, Schuetz, Catharina, Suan, Daniel, Rinchai, Darawan, Liu, Xian, Kane, Alisa, Ghillani-Dalbin, Pascale, Vong, Linda, Holland, Steve M., Gervais, Adrian, Droney, Luke, Cunningham-Rundles, Charlotte, Slatter, Mary A., Guffroy, Aurélien, Philippot, Quentin, DeRisi, Joseph L., Lazaro, Estibaliz, Boisson, Bertrand, Franco Gallego, William Alexander, McLean, Catriona, Poli, M. Cecilia, Barlogis, Vincent, Astudillo, Camila, Slade, Charlotte A., Zhang, Qian, Rubin, Tamar, Bengi Celik, Jale, Kuijpers, Taco, Boztuğ, Kaan, Katelaris, Constance H., Ducoux, Grégoire, Wong, Melanie, Charuel, Jean-Luc, Grombiříková, Hana, Eriksson, Daniel, Maglorius Renkilaraj, Majistor Raj Luxman, Zhang, Peng, Mahlaoui, Nizar, Warnatz, Klaus, Cobat, Aurélie, Hauck, Fabian, Servettaz, Amélie, Zhang, Yu, Delmonte, Ottavia M., Orrego, Julio, Mustillo, Peter, Su, Helen, Winter, Sarah, Imberti, Luisa, Berrios, David I., Rosain, Jérémie, Raedler, Johannes, Keller, Michael D., Rosenzweig, Sergio D., Pan-Hammarström, Qiang, Aladjidi, Nathalie, Emir

2023

Overview

Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I interferons (IFNs) 1 , 2 , conferring a predisposition to life-threatening COVID-19 pneumonia 3 . Here we report that patients with autosomal recessive NIK or RELB deficiency, or a specific type of autosomal-dominant NF-κB2 deficiency, also have neutralizing autoantibodies against type I IFNs and are at higher risk of getting life-threatening COVID-19 pneumonia. In patients with autosomal-dominant NF-κB2 deficiency, these autoantibodies are found only in individuals who are heterozygous for variants associated with both transcription (p52 activity) loss of function (LOF) due to impaired p100 processing to generate p52, and regulatory (IκBδ activity) gain of function (GOF) due to the accumulation of unprocessed p100, therefore increasing the inhibitory activity of IκBδ (hereafter, p52 LOF /IκBδ GOF ). By contrast, neutralizing autoantibodies against type I IFNs are not found in individuals who are heterozygous for NFKB2 variants causing haploinsufficiency of p100 and p52 (hereafter, p52 LOF /IκBδ LOF ) or gain-of-function of p52 (hereafter, p52 GOF /IκBδ LOF ). In contrast to patients with APS-1, patients with disorders of NIK, RELB or NF-κB2 have very few tissue-specific autoantibodies. However, their thymuses have an abnormal structure, with few AIRE-expressing medullary thymic epithelial cells. Human inborn errors of the alternative NF-κB pathway impair the development of AIRE-expressing medullary thymic epithelial cells, thereby underlying the production of autoantibodies against type I IFNs and predisposition to viral diseases. Inborn errors of the alternative NF-κB pathway in humans impair the development of AIRE-expressing medullary thymic epithelial cells, thereby underlying the production of autoantibodies against type I IFNs and predisposition to viral diseases

• Publisher: Nature Publishing Group UK,Nature Publishing Group
• Subject: 13/1 / 13/21 / 13/31 / 14/1 / 14/19 / 14/63 / 38 / 38/91 / 631/208/248 / 631/250/255 / AIRE Protein / Amino acids / Autoantibodies / Autoantibodies - immunology / Chicken pox / COVID-19 / COVID-19 - genetics / COVID-19 - immunology / Disease / Encephalitis / Epithelial cells / Epithelium / Fibroblasts / Gain of Function Mutation / Genetic Predisposition to Disease / Haploinsufficiency / Heterozygote / Humanities and Social Sciences / Humans / I-kappa B Proteins - deficiency / I-kappa B Proteins - genetics / Influenza / Interferon Type I - antagonists & inhibitors / Interferon Type I - immunology / Life Sciences / Loss of Function Mutation / multidisciplinary / Neutralizing / NF-kappa B - deficiency / NF-kappa B - genetics / NF-kappa B p52 Subunit - deficiency / NF-kappa B p52 Subunit - genetics / NF-kappaB-Inducing Kinase / NF-κB protein / Patients / Pneumonia / Pneumonia, Viral - genetics / Pneumonia, Viral - immunology / Polyendocrinopathies, Autoimmune / RelB protein / Science / Science (multidisciplinary) / Severe acute respiratory syndrome coronavirus 2 / Thymus / Thymus gland / Thymus Gland - abnormalities / Thymus Gland - immunology / Thymus Gland - pathology / Thyroid Epithelial Cells - metabolism / Thyroid Epithelial Cells - pathology / Transcription Factor RelB / Viral diseases / West Nile virus