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Use of Azithromycin and Death from Cardiovascular Causes
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Journal Article
Use of Azithromycin and Death from Cardiovascular Causes
2013
Overview
A recent study in a Medicaid population indicated an increased risk of cardiovascular death with azithromycin. The current study in a population in Denmark indicates no increase in risk. In a related Perspective, the FDA reviews its reasons for adding a warning of increased risk to the drug label.
Azithromycin is a macrolide antibiotic agent primarily used for the treatment of lower and upper respiratory infections and some sexually transmitted infections. This commonly used agent is considered to be generally free of serious adverse effects, including cardiac toxicity.
1
–
5
A recent observational study, however, showed that use of azithromycin was associated with a risk of death from cardiovascular causes that was 2 to 3 times as high as the risk associated with no use of antibiotics and the risk associated with amoxicillin treatment.
6
Given that certain other macrolides are known to prolong the QT interval and therefore are thought . . .
Publisher
Massachusetts Medical Society
Subject
/ Adult
/ Anti-Bacterial Agents - adverse effects
/ Anti-Bacterial Agents - therapeutic use
/ Antibiotics. Antiinfectious agents. Antiparasitic agents
/ Azithromycin - adverse effects
/ Azithromycin - therapeutic use
/ Biological and medical sciences
/ Cardiovascular Diseases - chemically induced
/ Cardiovascular Diseases - mortality
/ Death
/ Female
/ Humans
/ Male
/ Medicaid
/ Patients
/ Penicillin V - adverse effects
/ Penicillin V - therapeutic use
/ Pharmacology. Drug treatments
/ Risk
