Journal Article

Systemic immune‐inflammation index is associated with disease activity in patients with ankylosing spondylitis

Wu, Junlai, Chai, Kexia, Yan, Lifang

2021

Overview

Background The systemic immune‐inflammation index (SII) is a recently developed indicator for systemic inflammatory response. We aimed to explore the association between SII and disease activity in patients with ankylosing spondylitis (AS). Methods This retrospective study included 136 patients with AS and 63 healthy controls. Patients were divided into two groups according to Bath Ankylosing Spondylitis Disease Activity Index (BASDAI); active group (n = 60) and remission group (n = 76). Clinical, laboratory, and demographic characteristics were recorded. Spearman's correlation analysis was used to determine correlations of SII with C‐reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), and BASDAI in AS patients. Binary logistic regression analysis was used to assess risk factors for AS disease activity. Receiver operating characteristic curve analysis was used to evaluate the diagnostic value of SII and the above variables for the active group compared with the remission group. Results Systemic immune‐inflammation index levels were higher in AS patients than in healthy controls (p < 0.001). SII levels were higher in the active group than in the remission group (p < 0.001). For patients with AS, SII correlated positively with CRP (rs = 0.483, p < 0.001), ESR (rs = 0.374, p < 0.001), and BASDAI (rs = 0.667, p < 0.001). SII (OR = 1.009, 95% CI = 1.006–1.012, p < 0.001) was an independent risk factor affecting AS disease activity. The specificity and sensitivity of SII using a cutoff value of 513.2 were 83.33% and 86.84%, respectively, for the active group. Conclusion Systemic immune‐inflammation index was increased in AS. SII may be a novel indicator for monitoring AS disease activity. The systemic immune‐inflammation index (SII) is a developed indicator for systemic inflammatory response. This study showed that SII was higher in AS. This study reveals that SII may be a novel indicator for monitoring AS disease activity.

• Publisher: John Wiley & Sons, Inc,John Wiley and Sons Inc
• Subject: Adult / Ankylosing spondylitis / Antigens / Arthritis / Autoimmune diseases / Biomarkers / Blood / Blood diseases / Blood platelets / Blood Sedimentation / C-Reactive Protein - metabolism / Cardiovascular disease / Case-Control Studies / China - epidemiology / Correlation analysis / Demographics / disease activity / Erythrocyte sedimentation rate / Female / Humans / Inflammation / Inflammation - immunology / Inflammation - metabolism / Inflammation - physiopathology / inflammatory marker / inflammatory response / Laboratories / Lymphocytes / Male / Neutrophils / Normal distribution / Pain / Patients / Prognosis / Proteins / Regression analysis / Remission / Remission (Medicine) / Retrospective Studies / Risk factors / ROC Curve / Severity of Illness Index / Software / Spondylitis, Ankylosing - epidemiology / Spondylitis, Ankylosing - immunology / Spondylitis, Ankylosing - metabolism / Spondylitis, Ankylosing - pathology / systemic immune‐inflammation index