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A Randomized Trial of Prophylactic Antibiotics for Miscarriage Surgery

by Ditai, James , Bishop, Jonathan R.B , Mhango, Chisale , Unzia, Hellen , Tambala, Tayamika , Weeks, Andrew , Middleton, Lee , Mboma, Agnes , Chibwana, Jerome , Ekunait, John , Hewitt, Catherine A , Mphasa, Colleta , Qureshi, Rahat , Taulo, Frank , Arulkumaran, Sabaratnam , Chirwa, Agatha , Coomarasamy, Arri , Wilson, Amie , Ahmed, Iffat , Oladapo, Olufemi T , Lissauer, David , Zamora, Javier , Goranitis, Ilias , Roberts, Tracy , Acam, JaneFrances , Bar-Zeev, Sarah , Makiika, Joshua J , Mwalwanda, Caroline , Bhutta, Zulfiqar A , Ngalawesa, Theresa , Otim Tom, Charles , Iyaku, Margaret , Simon, Beatus , Merriel, Abi , Ismail, Humera , Mbaruku, Godfrey , Watts, Grace , Gulmezoglu, Ahmet M , Mataya, Ronald , Chiudzu, Grace , Desmond, Nicola , Daniels, Jane

in Abortion, Spontaneous - surgery / Administration, Oral / Adolescent / Adolescents / Adult / Africa South of the Sahara / Antibiotic Prophylaxis / Antibiotics / Clinical trials / Developing Countries / Disease prevention / Double-Blind Method / Doxycycline / Doxycycline - adverse effects / Doxycycline - therapeutic use / Evidence-based medicine / Female / Fever / Hospitals / Humans / Infections / Leukocytosis / Low income groups / Medical research / Metronidazole / Metronidazole - adverse effects / Metronidazole - therapeutic use / Miscarriage / Pakistan / Patients / Pelvic Infection - epidemiology / Pelvic Infection - prevention & control / Postoperative Complications - epidemiology / Postoperative Complications - prevention & control / Pregnancy / Preoperative Care / Surgery / Surgical outcomes / Teenagers / Treatment Outcome / Uterus / Vagina / Womens health

2019

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2019

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2019

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Journal Article

A Randomized Trial of Prophylactic Antibiotics for Miscarriage Surgery

Ditai, James,

Bishop, Jonathan R.B,

Mhango, Chisale,

Unzia, Hellen,

Tambala, Tayamika,

Weeks, Andrew,

Middleton, Lee,

Mboma, Agnes,

Chibwana, Jerome,

Ekunait, John,

Hewitt, Catherine A,

Mphasa, Colleta,

Qureshi, Rahat,

Taulo, Frank,

Arulkumaran, Sabaratnam,

Chirwa, Agatha,

Coomarasamy, Arri,

Wilson, Amie,

Ahmed, Iffat,

Oladapo, Olufemi T,

Lissauer, David,

Zamora, Javier,

Goranitis, Ilias,

Roberts, Tracy,

Acam, JaneFrances,

Bar-Zeev, Sarah,

Makiika, Joshua J,

Mwalwanda, Caroline,

Bhutta, Zulfiqar A,

Ngalawesa, Theresa,

Otim Tom, Charles,

Iyaku, Margaret,

Simon, Beatus,

Merriel, Abi,

Ismail, Humera,

Mbaruku, Godfrey,

Watts, Grace,

Gulmezoglu, Ahmet M,

Mataya, Ronald,

Chiudzu, Grace,

Desmond, Nicola,

Daniels, Jane

2019

Overview

In this trial in women undergoing miscarriage surgery in low-resource countries, antibiotic prophylaxis did not result in a significantly lower risk of pelvic infection, as defined by broad criteria, than placebo. However, benefit was observed in a secondary analysis that defined pelvic infection by strict criteria (signs of infection).

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Publisher

Massachusetts Medical Society

Subject

Abortion, Spontaneous - surgery

/ Administration, Oral

/ Adolescent

/ Adolescents

/ Adult

/ Africa South of the Sahara

/ Antibiotic Prophylaxis