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Dual-response fluorescent switching sensor for sequential detection of Fe3+ and vitamin C in hawthorn
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Dual-response fluorescent switching sensor for sequential detection of Fe3+ and vitamin C in hawthorn
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Journal Article
Dual-response fluorescent switching sensor for sequential detection of Fe3+ and vitamin C in hawthorn
2025
Overview
We developed a dual-mode fluorescence sensor based on 4,4′-stilbenedicarboxylic acid (H
2
SDC) for the sequential detection of iron ions (Fe
3+
) and vitamin C (VC) in hawthorn (genus
Crataegus
), a key traditional Chinese medicine (TCM). By leveraging the aggregation-induced emission (AIE) properties of H
2
SDC, the sensor quantifies Fe
3+
quantification via fluorescence quenching (“turn-off”) and subsequently detects VC through Fe
3+
reduction-triggered signal recovery (“turn-on”). This label-free strategy demonstrates high sensitivity, with linear ranges of 5.0–80.0 μmol L
−1
(Fe
3+
) and 5.0–40.0 μmol L
−1
(VC) and detection limits of 0.200 and 0.132 μmol L
−1
, respectively. Real-sample validation in Hawthorn matrices revealed excellent accuracy (spiked recoveries: 98.5–101.7% for Fe
3+
; 97.7–103.0% for VC) and reproducibility (RSD < 3.9%, n = 3). The platform integrates smartphone-assisted analysis to leverage concentration-dependent fluorescence transitions, offering potential for field-deployable threshold screening. As the first AIE-based sensor enabling sequential Fe
3+
/VC detection in herbal medicines, this work provides a rapid, cost-effective alternative to conventional instrumentation (e.g., HPLC/ICP-MS), supporting advancement of quality control for TCM modernization.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
