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Νanomaterial-Loaded Polymer Coating Prevents the In Vitro Growth of Candida albicans Biofilms on Silicone Biomaterials

by Chatzimoschou, Athanasios , Triaridis, Stefanos , Gravalidis, Christoforos , Meroni, Gabriele , Papaioannidou, Paraskevi , Soukouroglou, Prodromos , Tsikopoulos, Alexios , Drago, Lorenzo , Tsikopoulos, Konstantinos

in Absorbance / Al2O3 nanowires / Aluminum oxide / Biocompatibility / biofilm / Biofilms / Biomaterials / Biomedical materials / Candida albicans / Chemotherapy / Coatings / Colonization / Drug resistance / Fungi / Fungicides / Infections / Laryngeal cancer / Medical equipment / Medical research / Microorganisms / Nanomaterials / Nanoparticles / Nanotechnology / Nanowires / Plasma spraying / Polymer coatings / Polymers / prevention / Prostheses / Prosthetics / Scanning electron microscopy / Silicones / Surgical implants / Survival / TiO2 nanoparticles / Titanium dioxide / Toxicity / Transplants & implants / Voice prostheses

2023

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Νanomaterial-Loaded Polymer Coating Prevents the In Vitro Growth of Candida albicans Biofilms on Silicone Biomaterials

2023

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Νanomaterial-Loaded Polymer Coating Prevents the In Vitro Growth of Candida albicans Biofilms on Silicone Biomaterials

2023

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Journal Article

Νanomaterial-Loaded Polymer Coating Prevents the In Vitro Growth of Candida albicans Biofilms on Silicone Biomaterials

Chatzimoschou, Athanasios,

Triaridis, Stefanos,

Gravalidis, Christoforos,

Meroni, Gabriele,

Papaioannidou, Paraskevi,

Soukouroglou, Prodromos,

Tsikopoulos, Alexios,

Drago, Lorenzo,

Tsikopoulos, Konstantinos

2023

Overview

Early failure of silicone voice prostheses resulting from fungal colonization and biofilm formation poses a major concern in modern ear nose throat surgery. Therefore, developing new infection prevention techniques to prolong those implants’ survivorship is crucial. We designed an in vitro laboratory study to include nanomaterial-enhanced polymer coating with a plasma spraying technique against Candida albicans growth to address this issue. The anti-biofilm effects of high- and low-dose Al2O3 nanowire and TiO2 nanoparticle coatings were studied either alone or in conjunction with each other using checkerboard testing. It was demonstrated that both nanomaterials were capable of preventing fungal biofilm formation regardless of the anti-fungal agent concentration (median absorbance for high-dose Al2O3-enhanced polymer coating was 0.176 [IQR = 0.207] versus control absorbance of 0.805 [IQR = 0.381], p = 0.003 [98% biofilm reduction]; median absorbance for high-dose TiO2-enhanced polymer coating was 0.186 [IQR = 0.024] versus control absorbance of 0.766 [IQR = 0.458], p < 0.001 [93% biofilm reduction]). Furthermore, synergy was revealed when the Bliss model was applied. According to the findings of this work, it seems that simultaneous consideration of Al2O3 and TiO2 could further increase the existing antibiofilm potential of these nanomaterials and decrease the likelihood of localized toxicity.

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MDPI AG,MDPI

Subject

/ biofilm