Asset Details
Do you wish to reserve the book?
Plasma and CSF biomarkers of aging and cognitive decline in Caribbean vervets
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Plasma and CSF biomarkers of aging and cognitive decline in Caribbean vervets
Do you wish to request the book?
Plasma and CSF biomarkers of aging and cognitive decline in Caribbean vervets
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Plasma and CSF biomarkers of aging and cognitive decline in Caribbean vervets
2024
Overview
INTRODUCTION Vervets are non‐human primates that share high genetic homology with humans and develop amyloid beta (Aβ) pathology with aging. We expand current knowledge by examining Aβ pathology, aging, cognition, and biomarker proteomics. METHODS Amyloid immunoreactivity in the frontal cortex and temporal cortex/hippocampal regions from archived vervet brain samples ranging from young adulthood to old age was quantified. We also obtained cognitive scores, plasma samples, and cerebrospinal fluid (CSF) samples in additional animals. Plasma and CSF proteins were quantified with platforms utilizing human antibodies. RESULTS We found age‐related increases in Aβ deposition in both brain regions. Bioinformatic analyses assessed associations between biomarkers and age, sex, cognition, and CSF Aβ levels, revealing changes in proteins related to immune‐related inflammation, metabolism, and cellular processes. DISCUSSION Vervets are an effective model of aging and early‐stage Alzheimer's disease, and we provide translational biomarker data that both align with previous results in humans and provide a basis for future investigations. Highlights We found changes in immune and metabolic plasma biomarkers associated with age and cognition. Cerebrospinal fluid (CSF) biomarkers revealed changes in cell signaling indicative of adaptative processes. TNFRSF19 (TROY) and Artemin co‐localize with Alzheimer's disease pathology. Vervets are a relevant model for translational studies of early‐stage Alzheimer's disease.
Publisher
John Wiley and Sons Inc
Subject
/ Alzheimer Disease - cerebrospinal fluid
/ Amyloid beta-Peptides - blood
/ Amyloid beta-Peptides - cerebrospinal fluid
/ Animals
/ Biomarkers - cerebrospinal fluid
/ Brain
/ Cognitive Dysfunction - blood
/ Cognitive Dysfunction - cerebrospinal fluid
/ CSF
/ dementia
/ Female
/ Humans
/ Male
/ omics
/ plasma
/ vervets
