Journal Article

Spatial IMA1 regulation restricts root iron acquisition on MAMP perception

Geldner, Niko, Nobori, Tatsuya, Brent, Lukas, Armengot, Laia, He, Wenrong, Tsai, Huei-Hsuan, Ecker, Joseph R., Chen, Yintong, Platre, Matthieu Pierre, Busch, Wolfgang, Zhang, Ling, Cao, Min, Coll, Nuria S.

2024

Overview

Iron is critical during host–microorganism interactions 1 – 4 . Restriction of available iron by the host during infection is an important defence strategy, described as nutritional immunity 5 . However, this poses a conundrum for externally facing, absorptive tissues such as the gut epithelium or the plant root epidermis that generate environments that favour iron bioavailability. For example, plant roots acquire iron mostly from the soil and, when iron deficient, increase iron availability through mechanisms that include rhizosphere acidification and secretion of iron chelators 6 – 9 . Yet, the elevated iron bioavailability would also be beneficial for the growth of bacteria that threaten plant health. Here we report that microorganism-associated molecular patterns such as flagellin lead to suppression of root iron acquisition through a localized degradation of the systemic iron-deficiency signalling peptide Iron Man 1 (IMA1) in Arabidopsis thaliana . This response is also elicited when bacteria enter root tissues, but not when they dwell on the outer root surface. IMA1 itself has a role in modulating immunity in root and shoot, affecting the levels of root colonization and the resistance to a bacterial foliar pathogen. Our findings reveal an adaptive molecular mechanism of nutritional immunity that affects iron bioavailability and uptake, as well as immune responses. Microorganism-associated molecular patterns such as flagellin lead to suppression of root iron acquisition through localized degradation of the systemic iron-deficiency signalling peptide Iron Man 1 in Arabidopsis thaliana .

• Publisher: Nature Publishing Group UK,Nature Publishing Group
• Subject: 13/95 / 14/19 / 38 / 38/35 / 38/39 / 38/91 / 42 / 42/44 / 45 / 631/449/2169 / 631/449/2661/2666 / 631/449/2675 / 631/449/448 / 82/1 / 96 / Absorptivity / Acidification / Arabidopsis - immunology / Arabidopsis - metabolism / Arabidopsis - microbiology / Arabidopsis Proteins - metabolism / Bacteria / Bacteria - immunology / Bacteria - metabolism / Bioavailability / Epidermis / Epithelium / Flagellin - immunology / Gene Expression Regulation, Plant / Genes / Humanities and Social Sciences / Immune response / Immunity / Intracellular Signaling Peptides and Proteins - metabolism / Iron / Iron - metabolism / Iron deficiency / Life Sciences / Microorganisms / Molecular modelling / multidisciplinary / Nutrient deficiency / Pathogen-Associated Molecular Pattern Molecules - immunology / Pathogen-Associated Molecular Pattern Molecules - metabolism / Pathogens / Peptides / Plant Immunity / Plant roots / Plant Roots - immunology / Plant Roots - metabolism / Plant Roots - microbiology / Plant Shoots - immunology / Plant Shoots - metabolism / Plant Shoots - microbiology / Plant tissues / Rhizosphere / Science / Science (multidisciplinary)