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Comparative evaluation of efficacy and safety profile of rhubarb and α-keto analogs of essential amino acids supplementation in patients with diabetic nephropathy
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Comparative evaluation of efficacy and safety profile of rhubarb and α-keto analogs of essential amino acids supplementation in patients with diabetic nephropathy
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Journal Article
Comparative evaluation of efficacy and safety profile of rhubarb and α-keto analogs of essential amino acids supplementation in patients with diabetic nephropathy
2016
Overview
To determine the efficacy and safety profile of rhubarb and α-keto analogs of
essential amino acids supplementation in patients of diabetic nephropathy (DN), we studied 96
patients of DN attending a tertiary care center of the North India. The patients were randomly
divided into three equal interventional groups. Group I (control) that received conservative
management along with placebo, Group II (rhubarb) that received conservative management
along with rhubarb capsule (350 mg, thrice daily), and Group III [keto amino acid (KAA)] that
received conservative management along with α-keto analogs of essential amino acids (600 mg,
thrice daily). The treatment was continued for 12 weeks. Clinical and biochemical parameters
were assessed at 0, 4, 8, and 12 weeks of treatment. A progressive improvement in clinical features
and biochemical parameters was seen in all three groups after 12 weeks of treatment. The
KAA group showed more marked improvement in clinical features as well as biochemical parameters
compared to the rhubarb group. There was a reduction in blood glucose, blood urea, serum
creatinine, and 24 h total urine protein. There was an increase in hemoglobin, 24 h total urine
volume, and glomerular filtration rate. There was no statistical difference between the rhubarb
and KAA groups with respect to side effects (P > 0.05). Our study suggests that KAA is more
effective than rhubarb as add-on therapy with conservative management in patients of DN.
Publisher
Saudi Center for Organ Transplantation,Wolters Kluwer - Medknow Publications
Subject
