Asset Details
Do you wish to reserve the book?
Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice
Do you wish to request the book?
Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice
2017
Overview
The sexual differentiation paradigm contends that the female pattern of the reproductive system is established by default because the male reproductive tracts (Wolffian ducts) in the female degenerate owing to a lack of androgen. Here, we discovered that female mouse embryos lacking Coup-tfII (chicken ovalbumin upstream promoter transcription factor II) in the Wolffian duct mesenchyme became intersex—possessing both female and male reproductive tracts. Retention of Wolffian ducts was not caused by ectopic androgen production or action. Instead, enhanced phosphorylated extracellular signal-regulated kinase signaling in Wolffian duct epithelium was responsible for the retention of male structures in an androgen-independent manner. We thus suggest that elimination of Wolffian ducts in female embryos is actively promoted by COUP-TFII, which suppresses a mesenchyme-epithelium cross-talk responsible for Wolffian duct maintenance.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Animals
/ COUP Transcription Factor II - genetics
/ COUP Transcription Factor II - physiology
/ Ducts
/ Embryos
/ Extracellular signal-regulated kinase
/ Female
/ Females
/ Genitalia, Male - embryology
/ Male
/ Males
/ Mice
/ Receptors, Androgen - genetics
/ Receptors, Androgen - metabolism
/ Sex
/ Sex Differentiation - genetics
