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Eltrombopag Added to Immunosuppression in Severe Aplastic Anemia

by Dufour, Carlo , Halkes, Constantijn J.M , Clement, Laurence , Griffin, Morag , de Groot, Marco R , Cacace, Fabiana , Mear, Jean-Baptiste , Passweg, Jakob R , Smith, Alexander E , Rabian, Florence , Angelucci, Emanuele , Russell, Nigel H , Peffault de Latour, Régis , Marano, Luana , Palmisani, Elena , La Rocca, Ursula , Raymakers, Reinier A.P , Mufti, Ghulam J , Vallejo, Juan-Carlos , Praire, Aline , Barcellini, Wilma , Munir, Talha , Barraco, Fiorenza , Sánchez-Ortega, Isabel , Drexler, Beatrice , Xicoy, Blanca , Terwel, Sofie R , Jarque, Isidro , Forcade, Edouard , Iori, Anna-Paola , Tjon, Jennifer M.L , Cook, Riley , Muus, Petra , Socié, Gérard , Marsh, Judith C.W , Frieri, Camilla , van Lint, Maria-Teresa , Sureda, Anna , Sicre de Fontbrune, Flore , Risitano, Antonio M , Daguindau, Etienne , Kulasekararaj, Austin , Tavitian, Suzanne , Hill, Anita , Recher, Christian , Cavenagh, James , Iacobelli, Simona , Terriou, Louis , Nur, Erfan , Marotta, Serena

in Adolescent / Adult / Aged / Aged, 80 and over / Anemia / Anemia, Aplastic - drug therapy / Anemia, Aplastic - genetics / Anemia, Aplastic - therapy / Antilymphocyte serum / Antilymphocyte Serum - adverse effects / Antilymphocyte Serum - therapeutic use / Aplastic anemia / Benzoates - adverse effects / Benzoates - therapeutic use / Bone marrow / Cyclosporine - adverse effects / Cyclosporine - therapeutic use / Cyclosporins / Drug Therapy, Combination / Female / Globulins / Hematology / Humans / Hydrazines - adverse effects / Hydrazines - therapeutic use / Hypotheses / Immunosuppression / Immunosuppression Therapy / Immunosuppressive agents / Immunosuppressive Agents - adverse effects / Immunosuppressive Agents - therapeutic use / Life Sciences / Male / Middle Aged / Mutation / Myelodysplastic syndrome / Myelodysplastic syndromes / Neutrophils / Oncology / Progression-Free Survival / Prospective Studies / Pyrazoles - adverse effects / Pyrazoles - therapeutic use / R&D / Receptors, Thrombopoietin - agonists / Remission Induction / Research & development / Response rates / Thymocytes / Young Adult

2022

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Eltrombopag Added to Immunosuppression in Severe Aplastic Anemia

2022

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Eltrombopag Added to Immunosuppression in Severe Aplastic Anemia

2022

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Journal Article

Eltrombopag Added to Immunosuppression in Severe Aplastic Anemia

Dufour, Carlo,

Halkes, Constantijn J.M,

Clement, Laurence,

Griffin, Morag,

de Groot, Marco R,

Cacace, Fabiana,

Mear, Jean-Baptiste,

Passweg, Jakob R,

Smith, Alexander E,

Rabian, Florence,

Angelucci, Emanuele,

Russell, Nigel H,

Peffault de Latour, Régis,

Marano, Luana,

Palmisani, Elena,

La Rocca, Ursula,

Raymakers, Reinier A.P,

Mufti, Ghulam J,

Vallejo, Juan-Carlos,

Praire, Aline,

Barcellini, Wilma,

Munir, Talha,

Barraco, Fiorenza,

Sánchez-Ortega, Isabel,

Drexler, Beatrice,

Xicoy, Blanca,

Terwel, Sofie R,

Jarque, Isidro,

Forcade, Edouard,

Iori, Anna-Paola,

Tjon, Jennifer M.L,

Cook, Riley,

Muus, Petra,

Socié, Gérard,

Marsh, Judith C.W,

Frieri, Camilla,

van Lint, Maria-Teresa,

Sureda, Anna,

Sicre de Fontbrune, Flore,

Risitano, Antonio M,

Daguindau, Etienne,

Kulasekararaj, Austin,

Tavitian, Suzanne,

Hill, Anita,

Recher, Christian,

Cavenagh, James,

Iacobelli, Simona,

Terriou, Louis,

Nur, Erfan,

Marotta, Serena

2022

Overview

A randomized trial comparing immunosuppression (horse ATG and cyclosporine) with the same therapy plus eltrombopag showed more rapid and complete responses with the addition of eltrombopag. Severe adverse effects were similar in the two groups. Somatic mutations increased in both groups but did not lead to an increase in leukemia.

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Publisher

Massachusetts Medical Society

Subject

Adolescent

/ Adult

/ Aged

/ Aged, 80 and over

/ Anemia

/ Anemia, Aplastic - drug therapy

/ Anemia, Aplastic - genetics