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Effects of Serelaxin in Patients with Acute Heart Failure

by Wikström, Gerhard , Adams, Kirkwood F , Echeverría, Luis E , Špinar, Jindřich , Cotter, Gad , Dorobantu, Maria , Hua, Tsushung A , Filippatos, Gerasimos , Crespo-Leiro, Maria G , Squire, Iain , Sabarwal, Shalini V , Böhm, Michael , Cleland, John G.F , Goudev, Assen , Davison, Beth A , Greenberg, Barry H , Gimpelewicz, Claudio , Merkely, Béla , Stępińska, Janina , Goland, Sorel , Yilmaz, Mehmet B , Ponikowski, Piotr , Manga, Pravin , Van Mieghem, Walter , Teerlink, John R , Pang, Peter S , Levy, Phillip D , Holbro, Thomas , Metra, Marco , Bortman, Guillermo , Mueller, Christian , Silva-Cardoso, Jose , Anker, Stefan D , Arias-Mendoza, Alexandra , Szecsödy, Peter , Goncalvesová, Eva , Severin, Thomas , Voors, Adriaan A , Avendaño, Patricio , Lema-Osores, Juan , Ferrari, Roberto , Køber, Lars , Hagner, Nicole , Felker, G. Michael , McDonald, Kenneth , Cohen-Solal, Alain , von Lewinski, Dirk , Bacal, Fernando , Pieske, Burkert

in Acute Disease / Adaptation / Aged / Blood pressure / Blood Pressure - drug effects / Body weight / Cardiovascular Diseases - mortality / Committees / Congestive heart failure / Death / Design / Disease Progression / Double-Blind Method / Dyspnea / Female / Heart failure / Heart Failure - drug therapy / Heart Failure - mortality / Heart Failure - physiopathology / Hospitalization / Humans / Incidence / Infusions, Intravenous / Intravenous administration / Kidneys / Life Sciences / Male / Mortality / Patients / Peptides / Pregnancy / Radiography / Recombinant Proteins - adverse effects / Recombinant Proteins - pharmacology / Recombinant Proteins - therapeutic use / Relaxin / Relaxin - adverse effects / Relaxin - pharmacology / Relaxin - therapeutic use / Renal failure / Renal insufficiency / Respiration / Treatment Failure / Vasodilator Agents - adverse effects / Vasodilator Agents - therapeutic use

2019

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Effects of Serelaxin in Patients with Acute Heart Failure

2019

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Effects of Serelaxin in Patients with Acute Heart Failure

2019

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Journal Article

Effects of Serelaxin in Patients with Acute Heart Failure

Wikström, Gerhard,

Adams, Kirkwood F,

Echeverría, Luis E,

Špinar, Jindřich,

Cotter, Gad,

Dorobantu, Maria,

Hua, Tsushung A,

Filippatos, Gerasimos,

Crespo-Leiro, Maria G,

Squire, Iain,

Sabarwal, Shalini V,

Böhm, Michael,

Cleland, John G.F,

Goudev, Assen,

Davison, Beth A,

Greenberg, Barry H,

Gimpelewicz, Claudio,

Merkely, Béla,

Stępińska, Janina,

Goland, Sorel,

Yilmaz, Mehmet B,

Ponikowski, Piotr,

Manga, Pravin,

Van Mieghem, Walter,

Teerlink, John R,

Pang, Peter S,

Levy, Phillip D,

Holbro, Thomas,

Metra, Marco,

Bortman, Guillermo,

Mueller, Christian,

Silva-Cardoso, Jose,

Anker, Stefan D,

Arias-Mendoza, Alexandra,

Szecsödy, Peter,

Goncalvesová, Eva,

Severin, Thomas,

Voors, Adriaan A,

Avendaño, Patricio,

Lema-Osores, Juan,

Ferrari, Roberto,

Køber, Lars,

Hagner, Nicole,

Felker, G. Michael,

McDonald, Kenneth,

Cohen-Solal, Alain,

von Lewinski, Dirk,

Bacal, Fernando,

Pieske, Burkert

2019

Overview

In a randomized trial, 6545 patients with acute heart failure were assigned to either serelaxin or placebo in addition to standard care. There were no significant differences between the two groups in the incidence of death from cardiovascular causes at 180 days or worsening heart failure at 5 days.

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Publisher

Massachusetts Medical Society

Subject

Acute Disease

/ Adaptation

/ Aged

/ Blood pressure

/ Blood Pressure - drug effects

/ Body weight

/ Cardiovascular Diseases - mortality