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Long-Acting Cabotegravir and Rilpivirine for Maintenance of HIV-1 Suppression

by Ford, Susan L , Pokrovsky, Vadim , Patel, Parul , Richmond, Gary J , Williams, Peter E , Hudson, Krischan J , Baumgarten, Axel , Talarico, Christine L , Masiá, Mar , Huang, Jenny , Smith, Graham , Vanveggel, Simon , Swindells, Susan , Rizzardini, Giuliano , Smith, Kimberly Y , Mrus, Joseph , Margolis, David A , Chounta, Vasiliki , Latiff, Gulam , Bredeek, Fritz , Kim, Yeon-Sook , Spreen, William R , Cahn, Pedro , Harrington, Conn M , Andrade-Villanueva, Jaime-Federico , Crauwels, Herta , Parys, Wim

in Administration, Oral / Adult / Anti-HIV Agents - administration & dosage / Anti-HIV Agents - adverse effects / Anti-HIV Agents - blood / Anti-Retroviral Agents - therapeutic use / Antiretroviral drugs / Antiretroviral therapy / CD4 Lymphocyte Count / Drug dosages / Drug Resistance, Viral - genetics / Drug therapy / Drug Therapy, Combination / FDA approval / Female / HIV / HIV Infections - drug therapy / HIV-1 - genetics / HIV-1 - isolation & purification / Human immunodeficiency virus / Humans / Infections / Injection / Injections, Intramuscular - adverse effects / Integrase / Maintenance Chemotherapy / Male / Middle Aged / Mutation / Patient Reported Outcome Measures / Patient satisfaction / Patients / Pyridones - administration & dosage / Pyridones - adverse effects / Pyridones - blood / Ribonucleic acid / Rilpivirine - administration & dosage / Rilpivirine - adverse effects / Rilpivirine - blood / RNA / RNA, Viral - blood / Statistical analysis / Viral Load

2020

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Long-Acting Cabotegravir and Rilpivirine for Maintenance of HIV-1 Suppression

2020

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Long-Acting Cabotegravir and Rilpivirine for Maintenance of HIV-1 Suppression

2020

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Journal Article

Long-Acting Cabotegravir and Rilpivirine for Maintenance of HIV-1 Suppression

Ford, Susan L,

Pokrovsky, Vadim,

Patel, Parul,

Richmond, Gary J,

Williams, Peter E,

Hudson, Krischan J,

Baumgarten, Axel,

Talarico, Christine L,

Masiá, Mar,

Huang, Jenny,

Smith, Graham,

Vanveggel, Simon,

Swindells, Susan,

Rizzardini, Giuliano,

Smith, Kimberly Y,

Mrus, Joseph,

Margolis, David A,

Chounta, Vasiliki,

Latiff, Gulam,

Bredeek, Fritz,

Kim, Yeon-Sook,

Spreen, William R,

Cahn, Pedro,

Harrington, Conn M,

Andrade-Villanueva, Jaime-Federico,

Crauwels, Herta,

Parys, Wim

2020

Overview

Simplified treatment regimens for HIV management may increase adherence. In this open-label, randomized, controlled trial, longer-acting (monthly) injectable cabotegravir plus rilpivirine was compared with standard oral treatment. At 48 weeks, similar viral suppression was seen with the two regimens.

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Publisher

Massachusetts Medical Society

Subject

Administration, Oral

/ Adult

/ Anti-HIV Agents - administration & dosage

/ Anti-HIV Agents - adverse effects

/ Anti-HIV Agents - blood

/ Anti-Retroviral Agents - therapeutic use

/ Antiretroviral drugs