Asset Details
Do you wish to reserve the book?
IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease
Do you wish to request the book?
IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease
2011
Overview
To through light on the mechanisms underlying the stimulation and persistence of glial cell activation in Parkinsonism, we investigate the function of IFN-
γ
and TNF-
α
in experimental models of Parkinson's disease and analyze their relation with local glial cell activation. It was found that IFN-
γ
and TNF-
α
remained higher over the years in the serum and CNS of chronic Parkinsonian macaques than in untreated animals, accompanied by sustained glial activation (microglia and astroglia) in the substantia nigra
pars compacta
. Importantly, Parkinsonian monkeys showed persistent and increasing levels of IFN-
γ
R signaling in both microglial and astroglial cells. In addition, experiments performed in IFN-
γ
and TNF-
α
KO mice treated with MPTP revealed that, even before dopaminergic cell death can be observed, the presence of IFN-
γ
and TNF-
α
is crucial for microglial and astroglial activation, and, together, they have an important synergistic role. Both cytokines were necessary for the full level of activation to be attained in both microglial and astroglial cells. These results demonstrate that IFN-
γ
signaling, together with the contribution of TNF-
α
, have a critical and cell-specific role in stimulating and maintaining glial cell activation in Parkinsonism.
Publisher
Nature Publishing Group UK,Nature Publishing Group
