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ifn-γ-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury

by Serada, S , Tanabe, S , Kayama, H , Yamashita, T , Ishii, H , Ueno, M , Kubo, T , Takeda, K , Naka, T , Fujimoto, M

in 631/250/127/1213 / 631/250/1619/554/1898/1272 / 631/378/1687/1825 / 631/378/2596/1953 / Adoptive Transfer / Animals / Antibodies / Biochemistry / Biomedical and Life Sciences / Cell Biology / Cell Culture / Cells, Cultured / Female / Glial Cell Line-Derived Neurotrophic Factor - secretion / Immunology / Immunotherapy, Adoptive / Interferon-gamma - physiology / Interleukin-10 - secretion / Life Sciences / Macrophages - secretion / Mice / Mice, Inbred C57BL / Mice, Knockout / Microglia - secretion / Nerve Growth Factors - secretion / Original / original-article / Recovery of Function / Spinal Cord Injuries - immunology / Spinal Cord Injuries - therapy / Th1 Cells - secretion / Th1 Cells - transplantation / Up-Regulation

2013

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ifn-γ-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury

by Serada, S , Tanabe, S , Kayama, H , Yamashita, T , Ishii, H , Ueno, M , Kubo, T , Takeda, K , Naka, T , Fujimoto, M

2013

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ifn-γ-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury

by Serada, S , Tanabe, S , Kayama, H , Yamashita, T , Ishii, H , Ueno, M , Kubo, T , Takeda, K , Naka, T , Fujimoto, M

2013

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Journal Article

ifn-γ-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury

Serada, S,

Tanabe, S,

Kayama, H,

Yamashita, T,

Ishii, H,

Ueno, M,

Kubo, T,

Takeda, K,

Naka, T,

Fujimoto, M

2013

Overview

Transfer of type-1 helper T-conditioned (Th1-conditioned) cells promotes functional recovery with enhanced axonal remodeling after spinal cord injury (SCI). This study explored the molecular mechanisms underlying the beneficial effects of pro-inflammatory Th1-conditioned cells after SCI. The effect of Th1-conditioned cells from interferon-γ ( ifn-γ ) knockout mice ( ifn-γ −/− Th1 cells) on the recovery after SCI was reduced. Transfer of Th1-conditioned cells led to the activation of microglia (MG) and macrophages (MΦs), with interleukin 10 (IL-10) upregulation. This upregulation of IL-10 was reduced when ifn-γ −/− Th1 cells were transferred. Intrathecal neutralization of IL-10 in the spinal cord attenuated the effects of Th1-conditioned cells. Further, IL-10 is robustly secreted from Th1-conditioned cells in an ifn-γ -dependent manner. Th1-conditioned cells from interleukin 10 knockout ( il- 10 −/− ) mice had no effects on recovery from SCI. These findings demonstrate that ifn-γ -dependent secretion of IL-10 from Th1 cells, as well as native MG/MΦs, is required for the promotion of motor recovery after SCI.

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Nature Publishing Group UK,Nature Publishing Group

Subject

631/250/127/1213

/ 631/250/1619/554/1898/1272

/ Animals