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The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis
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The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis
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Journal Article
The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis
2007
Overview
Programmed cell death (PCD) in the
Drosophila
ovary occurs either during mid-oogenesis, resulting in degeneration of the entire egg chamber or during late oogenesis, to facilitate the development of the oocyte. PCD during oogenesis is regulated by mechanisms different from those that control cell death in other
Drosophila
tissues. We have analyzed the role of caspases in PCD of the female germline by examining caspase mutants and overexpressing caspase inhibitors. Imprecise
P-
element excision was used to generate mutants of the initiator caspase
strica.
While null mutants of
strica
or another initiator caspase,
dronc,
display no ovary phenotype, we find that
strica
exhibits redundancy with
dronc
, during both mid- and late oogenesis. Ovaries of double mutants contain defective mid-stage egg chambers similar to those reported previously in
dcp-1
mutants, and mature egg chambers with persisting nurse cell nuclei. In addition, the effector caspases
drice
and
dcp-1
also display redundant functions during late oogenesis, resulting in persisting nurse cell nuclei. These findings indicate that caspases are required for nurse cell death during mid-oogenesis, and participate in developmental nurse cell death during late oogenesis. This reveals a novel pathway of cell death in the ovary that utilizes
strica
,
dronc
,
dcp-1
and
drice
, and importantly illustrates strong redundancy among the caspases.
Publisher
Nature Publishing Group UK,Nature Publishing Group
