Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Spontaneous Remission of Acute Myeloid Leukemia: A Case Report

by Salgado-Sánchez, Rocío , Atance-Pasarisas, Mireia , Rodríguez-Pinilla, Socorro María , Cotti-Ferrari, María José , Alonso-Dominguez, Juan Manuel , Martínez-Díez, Yolanda , Blas, Carlos , Castaño-Bonilla, Tamara , Franganillo-Suárez, Aida , Lainez-González, Daniel , Llamas-Sillero, Pilar

in AML / Bone marrow / Case Report / Case reports / Cell cycle / Cloning / Cytogenetics / Cytokines / Flow cytometry / Immune system / Infections / Leukemia / Medical prognosis / molecular response / Mutation / Patients / Remission (Medicine) / Review boards / spontaneous remission

2022

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Spontaneous Remission of Acute Myeloid Leukemia: A Case Report

2022

Confirm

Do you wish to request the book?

Spontaneous Remission of Acute Myeloid Leukemia: A Case Report

2022

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Spontaneous Remission of Acute Myeloid Leukemia: A Case Report

Salgado-Sánchez, Rocío,

Atance-Pasarisas, Mireia,

Rodríguez-Pinilla, Socorro María,

Cotti-Ferrari, María José,

Alonso-Dominguez, Juan Manuel,

Martínez-Díez, Yolanda,

Blas, Carlos,

Castaño-Bonilla, Tamara,

Franganillo-Suárez, Aida,

Lainez-González, Daniel,

Llamas-Sillero, Pilar

2022

Overview

Spontaneous remissions (SRs) in acute myeloid leukemia (AML) are infrequent, poorly documented and transient. Similarly, morphological and cytogenetic complete remissions (CR) under azacitidine treatment are scarce. We report a 71-year-old man with a secondary AML arising from essential thrombocythemia (ET), who developed an SR after discontinuation of azacitidine following a respiratory infection (four courses were administered). The distinctive feature of our case is the depth of the achieved CR, documented by next-generation sequencing (NGS) techniques. We also detected persistence of molecular lesions that might already have been present in the previous ET clone. Our patient relapsed 5 months after achieving CR. We conclude that our patient showed a spontaneous remission of his AML rather than an exquisite response to azacitidine. We hypothesize that the concurrent respiratory infection, or any other unknown trigger, might have activated his immune system forcing the leukemic stem cell to enter a quiescent state through a yet unexplained mechanism.

Share this book

Add to My Shelf

Publisher

MDPI AG,MDPI

Subject

/ Cloning