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Mass Recalibration of FT-ICR Mass Spectrometry Imaging Data Using the Average Frequency Shift of Ambient Ions
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Mass Recalibration of FT-ICR Mass Spectrometry Imaging Data Using the Average Frequency Shift of Ambient Ions
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Journal Article
Mass Recalibration of FT-ICR Mass Spectrometry Imaging Data Using the Average Frequency Shift of Ambient Ions
2013
Overview
Achieving and maintaining high mass measurement accuracy (MMA) throughout a mass spectrometry imaging (MSI) experiment is vital to the identification of the observed ions. However, when using FTMS instruments, fluctuations in the total ion abundance at each pixel due to inherent biological variation in the tissue section can introduce space charge effects that systematically shift the observed mass. Herein we apply a recalibration based on the observed cyclotron frequency shift of ions found in the ambient laboratory environment, polydimethylcyclosiloxanes (PDMS). This calibration method is capable of achieving part per billion (ppb) mass accuracy with relatively high precision for an infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) MSI dataset. Comparisons with previously published mass calibration approaches are also presented.
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Publisher
Springer-Verlag,Springer Nature B.V
Subject
/ Animals
/ Chemistry and Materials Science
/ Ions
/ Lasers
/ Mass Spectrometry - statistics & numerical data
/ Mice
/ Molecular Imaging - statistics & numerical data
/ Spectrometry, Mass, Electrospray Ionization - methods
/ Spectrometry, Mass, Electrospray Ionization - statistics & numerical data
/ Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
/ Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - statistics & numerical data
