Asset Details
Do you wish to reserve the book?
Associations between peripheral blood mitochondrial genomic variants and gestational diabetes mellitus and postpartum abnormal glucose metabolism
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Associations between peripheral blood mitochondrial genomic variants and gestational diabetes mellitus and postpartum abnormal glucose metabolism
Do you wish to request the book?
Associations between peripheral blood mitochondrial genomic variants and gestational diabetes mellitus and postpartum abnormal glucose metabolism
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Associations between peripheral blood mitochondrial genomic variants and gestational diabetes mellitus and postpartum abnormal glucose metabolism
2025
Overview
Aims/Introduction The aim of the study was to investigate the association of single nucleotide polymorphisms, haplogroups, and copy number in the D‐loop region of mitochondrial DNA (mtDNA) with the genetic susceptibility to gestational diabetes mellitus (GDM) and postpartum abnormal glucose metabolism (AGM). Materials and Methods This was a case–control study in which peripheral blood samples were collected from 500 GDM patients and 500 normal pregnant women from 14 to 20 weeks of pregnancy. The sequence of the D‐loop region of mtDNA was detected by Sanger sequencing, and the copy number of mtDNA was detected by qPCR. Results Analysis of SNPs in the D‐loop region of mtDNA showed that 249d was a risk factor and 309+C and 16193+C were protective factors for GDM. The mtDNA haplogroups R9 and M* were a risk factor and protective factor for GDM, respectively. Compared to the group with normal postpartum glucose tolerance, the haplogroups M7b and N9a were associated with an increased risk of AGM. The whole blood mtDNA copy number was lower in the GDM group than in the control group and was also lower in the postpartum AGM group than in the postpartum normal group. The plasma free mtDNA copy number was higher in the GDM group than in the control group, and higher in the postpartum AGM group than in the normal postpartum group. Conclusions Mitochondrial genomic variants are associated with the risk of GDM and postpartum AGM, and may provide some etiologic evidence for GDM and postpartum AGM. Mitochondrial DNA D‐loop region SNPs, mitochondrial DNA haplogroups, and mitochondrial DNA copy number are risk factors for GDM and postpartum AGM and to provide evidence to better understand the etiology of GDM.
Publisher
John Wiley & Sons, Inc,Wiley
Subject
/ Age
/ Diabetes
/ Diabetes, Gestational - blood
/ Diabetes, Gestational - genetics
/ Disease
/ DNA, Mitochondrial - genetics
/ Female
/ Genetic Predisposition to Disease
/ Genomics
/ Gestational diabetes mellitus
/ Glucose
/ Glucose Metabolism Disorders - blood
/ Glucose Metabolism Disorders - genetics
/ Humans
/ Mitochondrial DNA copy number
/ Mitochondrial DNA haplogroup
/ Mutation
/ Original
/ Plasma
/ Polymorphism, Single Nucleotide
