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Reservoir Targeted Vaccine Against Borrelia burgdorferi: A New Strategy to Prevent Lyme Disease Transmission
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Reservoir Targeted Vaccine Against Borrelia burgdorferi: A New Strategy to Prevent Lyme Disease Transmission
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Journal Article
Reservoir Targeted Vaccine Against Borrelia burgdorferi: A New Strategy to Prevent Lyme Disease Transmission
2014
Overview
A high prevalence of infection with Borrelia burgdorferi in ixodid ticks is correlated with a high incidence of Lyme disease. The transmission of B. burgdorferi to humans can be disrupted by targeting 2 key elements in its enzootic cycle: the reservoir host and the tick vector. In a prospective 5-year field trial, we show that oral vaccination of wild white-footed mice resulted in outer surface protein A-specific seropositivity that led to reductions of 23% and 76% in the nymphal infection prevalence in a cumulative, time-dependent manner (2 and 5 years, respectively), whereas the proportion of infected ticks recovered from control plots varied randomly over time. Significant decreases in tick infection prevalence were observed within 3 years of vaccine deployment. Implementation of such a long-term public health measure could substantially reduce the risk of human exposure to Lyme disease.
Publisher
Oxford University Press
Subject
/ Animals
/ Antigens, Surface - immunology
/ BACTERIA
/ Bacterial Outer Membrane Proteins - immunology
/ Bacterial Vaccines - immunology
/ Biological and medical sciences
/ Borrelia burgdorferi - immunology
/ Disease Reservoirs - microbiology
/ Disease Reservoirs - veterinary
/ Fundamental and applied biological sciences. Psychology
/ Ixodidae
/ Lyme Disease - prevention & control
/ Lyme Disease Vaccines - immunology
/ Mice
/ Ticks
/ Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
